node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NEDD4 | SCNN1A | ENSP00000345530 | ENSP00000353292 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.998 |
NEDD4 | SCNN1B | ENSP00000345530 | ENSP00000345751 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.999 |
NEDD4 | SCNN1G | ENSP00000345530 | ENSP00000300061 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, gamma subunit | 0.998 |
NEDD4 | SGK1 | ENSP00000345530 | ENSP00000356832 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase 1 | 0.993 |
NEDD4 | SGK2 | ENSP00000345530 | ENSP00000340608 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase 2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase | 0.455 |
NEDD4 | SGK3 | ENSP00000345530 | ENSP00000262211 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase family, member 3; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels- SCNN1A/ENAC and SCN5A, K(+) channels- KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels- TRPV5 and TRPV6, chloride channel- BSND, creatine transporter- SLC6A8, Na(+)/dicarboxylate cotransporter- SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter- SLC34A2/NAPI-2B, amino acid transporters- SLC1A5/ASCT2 and [...] | 0.775 |
NEDD4 | UBC | ENSP00000345530 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
NEDD4 | WNK4 | ENSP00000345530 | ENSP00000246914 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.468 |
NEDD4L | SCNN1A | ENSP00000383199 | ENSP00000353292 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.999 |
NEDD4L | SCNN1B | ENSP00000383199 | ENSP00000345751 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.999 |
NEDD4L | SCNN1G | ENSP00000383199 | ENSP00000300061 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, gamma subunit | 0.999 |
NEDD4L | SGK1 | ENSP00000383199 | ENSP00000356832 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase 1 | 0.999 |
NEDD4L | SGK2 | ENSP00000383199 | ENSP00000340608 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase 2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase | 0.966 |
NEDD4L | SGK3 | ENSP00000383199 | ENSP00000262211 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase family, member 3; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels- SCNN1A/ENAC and SCN5A, K(+) channels- KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels- TRPV5 and TRPV6, chloride channel- BSND, creatine transporter- SLC6A8, Na(+)/dicarboxylate cotransporter- SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter- SLC34A2/NAPI-2B, amino acid transporters- SLC1A5/ASCT2 and [...] | 0.996 |
NEDD4L | UBC | ENSP00000383199 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
NEDD4L | WNK4 | ENSP00000383199 | ENSP00000246914 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.864 |
NEDD4L | WWP1 | ENSP00000383199 | ENSP00000265428 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.929 |
SCNN1A | NEDD4 | ENSP00000353292 | ENSP00000345530 | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.998 |
SCNN1A | NEDD4L | ENSP00000353292 | ENSP00000383199 | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.999 |
SCNN1A | SCNN1B | ENSP00000353292 | ENSP00000345751 | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.983 |