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STRINGSTRING
ZNF260 ZNF260 SLC30A5 SLC30A5 SETD2 SETD2 CBWD3 CBWD3 SLC30A10 SLC30A10 PGM5 PGM5 FAM189A2 FAM189A2 FAM122A FAM122A C9orf135 C9orf135 PTAR1 PTAR1 TMEM252 TMEM252
"CBWD3" - COBW domain containing 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBWD3COBW domain containing 3 (395 aa)    
Predicted Functional Partners:
TMEM252
transmembrane protein 252 (170 aa)
             score_image   0.658
SLC30A5
solute carrier family 30 (zinc transporter), member 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (765 aa)
       score_image     score_image   0.632
FAM189A2
family with sequence similarity 189, member A2 (450 aa)
             score_image   0.585
C9orf135
chromosome 9 open reading frame 135 (229 aa)
             score_image   0.582
SETD2
SET domain containing 2 (2564 aa)
       score_image     score_image   0.574
SLC30A10
solute carrier family 30, member 10; May be involved in zinc transport out of the cell, being a zinc-efflux transporter (By similarity) (485 aa)
             score_image   0.542
FAM122A
family with sequence similarity 122A (287 aa)
             score_image   0.536
PTAR1
protein prenyltransferase alpha subunit repeat containing 1 (402 aa)
             score_image   0.507
ZNF260
zinc finger protein 260; Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity) (412 aa)
             score_image   0.505
PGM5
phosphoglucomutase 5 (567 aa)
             score_image   0.504
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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