node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY5 | ADCY6 | ENSP00000419361 | ENSP00000311405 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | 0.902 |
ADCY5 | ADCY7 | ENSP00000419361 | ENSP00000254235 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.969 |
ADCY5 | ADCY8 | ENSP00000419361 | ENSP00000286355 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity) | 0.910 |
ADCY5 | ADCY9 | ENSP00000419361 | ENSP00000294016 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 0.934 |
ADCY5 | PRKACA | ENSP00000419361 | ENSP00000309591 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.980 |
ADCY5 | PRKACB | ENSP00000419361 | ENSP00000359719 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | protein kinase, cAMP-dependent, catalytic, beta | 0.953 |
ADCY5 | PRKACG | ENSP00000419361 | ENSP00000366488 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus | 0.953 |
ADCY5 | PRKAR1A | ENSP00000419361 | ENSP00000351410 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.970 |
ADCY5 | PRKAR1B | ENSP00000419361 | ENSP00000353415 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.969 |
ADCY6 | ADCY5 | ENSP00000311405 | ENSP00000419361 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.902 |
ADCY6 | ADCY7 | ENSP00000311405 | ENSP00000254235 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.944 |
ADCY6 | ADCY8 | ENSP00000311405 | ENSP00000286355 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity) | 0.909 |
ADCY6 | ADCY9 | ENSP00000311405 | ENSP00000294016 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 0.933 |
ADCY6 | PRKACA | ENSP00000311405 | ENSP00000309591 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.953 |
ADCY6 | PRKACB | ENSP00000311405 | ENSP00000359719 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | protein kinase, cAMP-dependent, catalytic, beta | 0.954 |
ADCY6 | PRKACG | ENSP00000311405 | ENSP00000366488 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus | 0.953 |
ADCY6 | PRKAR1A | ENSP00000311405 | ENSP00000351410 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.970 |
ADCY6 | PRKAR1B | ENSP00000311405 | ENSP00000353415 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.970 |
ADCY7 | ADCY5 | ENSP00000254235 | ENSP00000419361 | adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.969 |
ADCY7 | ADCY6 | ENSP00000254235 | ENSP00000311405 | adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | 0.944 |