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CHERP CHERP EIF4A3 EIF4A3 MAGOH MAGOH PIAS2 PIAS2 UBC UBC LMF2 LMF2 SCAF1 SCAF1 PRR12 PRR12 BCL2L12 BCL2L12 SCAF8 SCAF8 SCAF4 SCAF4
"SCAF1" - SR-related CTD-associated factor 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SCAF1SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) (1312 aa)    
Predicted Functional Partners:
MAGOH
mago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] (146 aa)
        score_image       0.996
UBC
ubiquitin C (685 aa)
        score_image       0.975
SCAF4
SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) (1147 aa)
            score_image   0.767
EIF4A3
eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] (411 aa)
        score_image       0.601
PIAS2
protein inhibitor of activated STAT, 2; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Bin [...] (621 aa)
        score_image       0.556
SCAF8
SR-related CTD-associated factor 8; May play a role in mRNA processing (1271 aa)
            score_image   0.531
PRR12
proline rich 12 (2036 aa)
            score_image   0.517
BCL2L12
BCL2-like 12 (proline rich) (334 aa)
            score_image   0.487
CHERP
calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation (916 aa)
            score_image   0.407
LMF2
lipase maturation factor 2; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity) (707 aa)
            score_image   0.407
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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