node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2L12 | PRR12 | ENSP00000246785 | ENSP00000394510 | BCL2-like 12 (proline rich) | proline rich 12 | 0.513 |
BCL2L12 | SCAF1 | ENSP00000246785 | ENSP00000353769 | BCL2-like 12 (proline rich) | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | 0.487 |
BCL2L12 | UBC | ENSP00000246785 | ENSP00000344818 | BCL2-like 12 (proline rich) | ubiquitin C | 0.837 |
CHERP | SCAF1 | ENSP00000439856 | ENSP00000353769 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | 0.407 |
CHERP | UBC | ENSP00000439856 | ENSP00000344818 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | ubiquitin C | 0.893 |
EIF4A3 | MAGOH | ENSP00000269349 | ENSP00000360525 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | mago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] | 0.999 |
EIF4A3 | SCAF1 | ENSP00000269349 | ENSP00000353769 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | 0.601 |
EIF4A3 | UBC | ENSP00000269349 | ENSP00000344818 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | ubiquitin C | 0.994 |
LMF2 | SCAF1 | ENSP00000424381 | ENSP00000353769 | lipase maturation factor 2; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity) | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | 0.407 |
LMF2 | UBC | ENSP00000424381 | ENSP00000344818 | lipase maturation factor 2; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity) | ubiquitin C | 0.721 |
MAGOH | EIF4A3 | ENSP00000360525 | ENSP00000269349 | mago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | 0.999 |
MAGOH | SCAF1 | ENSP00000360525 | ENSP00000353769 | mago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | 0.996 |
MAGOH | UBC | ENSP00000360525 | ENSP00000344818 | mago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] | ubiquitin C | 0.927 |
PIAS2 | SCAF1 | ENSP00000465676 | ENSP00000353769 | protein inhibitor of activated STAT, 2; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Bin [...] | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | 0.556 |
PIAS2 | UBC | ENSP00000465676 | ENSP00000344818 | protein inhibitor of activated STAT, 2; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Bin [...] | ubiquitin C | 0.928 |
PRR12 | BCL2L12 | ENSP00000394510 | ENSP00000246785 | proline rich 12 | BCL2-like 12 (proline rich) | 0.513 |
PRR12 | SCAF1 | ENSP00000394510 | ENSP00000353769 | proline rich 12 | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | 0.517 |
PRR12 | UBC | ENSP00000394510 | ENSP00000344818 | proline rich 12 | ubiquitin C | 0.483 |
SCAF1 | BCL2L12 | ENSP00000353769 | ENSP00000246785 | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | BCL2-like 12 (proline rich) | 0.487 |
SCAF1 | CHERP | ENSP00000353769 | ENSP00000439856 | SR-related CTD-associated factor 1; May function in pre-mRNA splicing (By similarity) | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | 0.407 |