| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ERI3 | SLC6A9 | ENSP00000361331 | ENSP00000353791 | ERI1 exoribonuclease family member 3 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission | 0.565 |
| ERI3 | UBC | ENSP00000361331 | ENSP00000344818 | ERI1 exoribonuclease family member 3 | ubiquitin C | 0.721 |
| GABRR1 | PRKCA | ENSP00000412673 | ENSP00000408695 | gamma-aminobutyric acid (GABA) A receptor, rho 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | 0.576 |
| GABRR1 | SLC32A1 | ENSP00000412673 | ENSP00000217420 | gamma-aminobutyric acid (GABA) A receptor, rho 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission | solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles | 0.532 |
| GABRR1 | SLC6A9 | ENSP00000412673 | ENSP00000353791 | gamma-aminobutyric acid (GABA) A receptor, rho 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission | solute carrier family 6 (neurotransmitter transporter, glycine), member 9; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission | 0.624 |
| HMGN2 | HMGN3 | ENSP00000355228 | ENSP00000341267 | high mobility group nucleosomal binding domain 2; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity) | high mobility group nucleosomal binding domain 3; Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration i [...] | 0.755 |
| HMGN2 | PRKCA | ENSP00000355228 | ENSP00000408695 | high mobility group nucleosomal binding domain 2; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity) | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | 0.569 |
| HMGN2 | SLC6A9 | ENSP00000355228 | ENSP00000353791 | high mobility group nucleosomal binding domain 2; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity) | solute carrier family 6 (neurotransmitter transporter, glycine), member 9; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission | 0.512 |
| HMGN2 | THRB | ENSP00000355228 | ENSP00000348827 | high mobility group nucleosomal binding domain 2; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity) | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.440 |
| HMGN2 | UBC | ENSP00000355228 | ENSP00000344818 | high mobility group nucleosomal binding domain 2; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity) | ubiquitin C | 0.815 |
| HMGN3 | HMGN2 | ENSP00000341267 | ENSP00000355228 | high mobility group nucleosomal binding domain 3; Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration i [...] | high mobility group nucleosomal binding domain 2; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity) | 0.755 |
| HMGN3 | SLC6A9 | ENSP00000341267 | ENSP00000353791 | high mobility group nucleosomal binding domain 3; Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration i [...] | solute carrier family 6 (neurotransmitter transporter, glycine), member 9; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission | 0.971 |
| HMGN3 | THRB | ENSP00000341267 | ENSP00000348827 | high mobility group nucleosomal binding domain 3; Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration i [...] | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.505 |
| HMGN3 | UBC | ENSP00000341267 | ENSP00000344818 | high mobility group nucleosomal binding domain 3; Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration i [...] | ubiquitin C | 0.721 |
| PRKCA | GABRR1 | ENSP00000408695 | ENSP00000412673 | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | gamma-aminobutyric acid (GABA) A receptor, rho 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission | 0.576 |
| PRKCA | HMGN2 | ENSP00000408695 | ENSP00000355228 | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | high mobility group nucleosomal binding domain 2; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity) | 0.569 |
| PRKCA | SLC6A9 | ENSP00000408695 | ENSP00000353791 | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | solute carrier family 6 (neurotransmitter transporter, glycine), member 9; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission | 0.576 |
| PRKCA | UBC | ENSP00000408695 | ENSP00000344818 | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | ubiquitin C | 0.981 |
| SLC1A4 | SLC6A9 | ENSP00000234256 | ENSP00000353791 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence | solute carrier family 6 (neurotransmitter transporter, glycine), member 9; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission | 0.515 |
| SLC1A4 | UBC | ENSP00000234256 | ENSP00000344818 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence | ubiquitin C | 0.807 |
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