| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM167A | TRPM6 | ENSP00000284486 | ENSP00000354006 | family with sequence similarity 167, member A | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.700 |
| FAM167A | UHRF1BP1 | ENSP00000284486 | ENSP00000192788 | family with sequence similarity 167, member A | UHRF1 binding protein 1; May act as a negative regulator of cell growth | 0.776 |
| FOS | INS | ENSP00000306245 | ENSP00000250971 | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.949 |
| FOS | TRPM6 | ENSP00000306245 | ENSP00000354006 | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.813 |
| INS | FOS | ENSP00000250971 | ENSP00000306245 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] | 0.949 |
| INS | TRPM6 | ENSP00000250971 | ENSP00000354006 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.836 |
| KCNA6 | TRPM6 | ENSP00000280684 | ENSP00000354006 | potassium voltage-gated channel, shaker-related subfamily, member 6; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.656 |
| MRS2 | SLC41A1 | ENSP00000367637 | ENSP00000356105 | MRS2 magnesium homeostasis factor homolog (S. cerevisiae); Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix | solute carrier family 41, member 1; Acts as a magnesium transporter that is responsive to magnesium balance | 0.756 |
| MRS2 | TRPM6 | ENSP00000367637 | ENSP00000354006 | MRS2 magnesium homeostasis factor homolog (S. cerevisiae); Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.736 |
| MSRB1 | TRPM6 | ENSP00000355084 | ENSP00000354006 | methionine sulfoxide reductase B1 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.815 |
| NPR2 | TRPM6 | ENSP00000341083 | ENSP00000354006 | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.753 |
| SLC41A1 | MRS2 | ENSP00000356105 | ENSP00000367637 | solute carrier family 41, member 1; Acts as a magnesium transporter that is responsive to magnesium balance | MRS2 magnesium homeostasis factor homolog (S. cerevisiae); Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix | 0.756 |
| SLC41A1 | TRPM6 | ENSP00000356105 | ENSP00000354006 | solute carrier family 41, member 1; Acts as a magnesium transporter that is responsive to magnesium balance | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | 0.715 |
| TRPM6 | FAM167A | ENSP00000354006 | ENSP00000284486 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | family with sequence similarity 167, member A | 0.700 |
| TRPM6 | FOS | ENSP00000354006 | ENSP00000306245 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] | 0.813 |
| TRPM6 | INS | ENSP00000354006 | ENSP00000250971 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.836 |
| TRPM6 | KCNA6 | ENSP00000354006 | ENSP00000280684 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | potassium voltage-gated channel, shaker-related subfamily, member 6; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient | 0.656 |
| TRPM6 | MRS2 | ENSP00000354006 | ENSP00000367637 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | MRS2 magnesium homeostasis factor homolog (S. cerevisiae); Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix | 0.736 |
| TRPM6 | MSRB1 | ENSP00000354006 | ENSP00000355084 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | methionine sulfoxide reductase B1 | 0.815 |
| TRPM6 | NPR2 | ENSP00000354006 | ENSP00000341083 | transient receptor potential cation channel, subfamily M, member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) | 0.753 |
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