SCUBE1 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SCUBE1

signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology (988 aa)

Predicted Functional Partners:

CDH1

0.699

CDH3

0.688

TUBGCP6

0.608

SCUBE2

0.586

SCUBE3

0.583

DNAL4

0.525

C1S

0.467

ANGPTL6

0.431

RDH10

0.420

MRPL12

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPTL6	SCUBE1	ENSP00000253109	ENSP00000354080	angiopoietin-like 6; May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	0.431
C1S	SCUBE1	ENSP00000328173	ENSP00000354080	complement component 1, s subcomponent	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	0.467
CDH1	CDH3	ENSP00000261769	ENSP00000264012	cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7	cadherin 3, type 1, P-cadherin (placental); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	0.956
CDH1	SCUBE1	ENSP00000261769	ENSP00000354080	cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	0.699
CDH1	SCUBE2	ENSP00000261769	ENSP00000429969	cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7	signal peptide, CUB domain, EGF-like 2	0.806
CDH3	CDH1	ENSP00000264012	ENSP00000261769	cadherin 3, type 1, P-cadherin (placental); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7	0.956
CDH3	SCUBE1	ENSP00000264012	ENSP00000354080	cadherin 3, type 1, P-cadherin (placental); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	0.688
DNAL4	SCUBE1	ENSP00000216068	ENSP00000354080	dynein, axonemal, light chain 4; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity)	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	0.525
DNAL4	TUBGCP6	ENSP00000216068	ENSP00000248846	dynein, axonemal, light chain 4; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity)	tubulin, gamma complex associated protein 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.628
MRPL12	SCUBE1	ENSP00000333837	ENSP00000354080	mitochondrial ribosomal protein L12	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	0.416
RDH10	SCUBE1	ENSP00000240285	ENSP00000354080	retinol dehydrogenase 10 (all-trans); Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	0.420
SCUBE1	ANGPTL6	ENSP00000354080	ENSP00000253109	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	angiopoietin-like 6; May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure	0.431
SCUBE1	C1S	ENSP00000354080	ENSP00000328173	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	complement component 1, s subcomponent	0.467
SCUBE1	CDH1	ENSP00000354080	ENSP00000261769	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7	0.699
SCUBE1	CDH3	ENSP00000354080	ENSP00000264012	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	cadherin 3, type 1, P-cadherin (placental); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	0.688
SCUBE1	DNAL4	ENSP00000354080	ENSP00000216068	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	dynein, axonemal, light chain 4; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity)	0.525
SCUBE1	MRPL12	ENSP00000354080	ENSP00000333837	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	mitochondrial ribosomal protein L12	0.416
SCUBE1	RDH10	ENSP00000354080	ENSP00000240285	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	retinol dehydrogenase 10 (all-trans); Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol	0.420
SCUBE1	SCUBE2	ENSP00000354080	ENSP00000429969	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	signal peptide, CUB domain, EGF-like 2	0.586
SCUBE1	SCUBE3	ENSP00000354080	ENSP00000274938	signal peptide, CUB domain, EGF-like 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression	0.583

page 1 of 2

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About