node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC5 | HSPA1A | ENSP00000354111 | ENSP00000364802 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 1A | 0.942 |
DNAJC5 | HSPA1B | ENSP00000354111 | ENSP00000364801 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 1B | 0.933 |
DNAJC5 | HSPA1L | ENSP00000354111 | ENSP00000364805 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 1-like | 0.933 |
DNAJC5 | HSPA2 | ENSP00000354111 | ENSP00000247207 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 2; In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage | 0.933 |
DNAJC5 | HSPA4 | ENSP00000354111 | ENSP00000302961 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 4 | 0.935 |
DNAJC5 | HSPA5 | ENSP00000354111 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.934 |
DNAJC5 | HSPA6 | ENSP00000354111 | ENSP00000310219 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 6 (HSP70B’); In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity) | 0.934 |
DNAJC5 | HSPA8 | ENSP00000354111 | ENSP00000227378 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.995 |
DNAJC5 | SGTA | ENSP00000354111 | ENSP00000221566 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity | 0.932 |
DNAJC5 | SYT1 | ENSP00000354111 | ENSP00000261205 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.950 |
HSPA1A | DNAJC5 | ENSP00000364802 | ENSP00000354111 | heat shock 70kDa protein 1A | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | 0.942 |
HSPA1A | HSPA4 | ENSP00000364802 | ENSP00000302961 | heat shock 70kDa protein 1A | heat shock 70kDa protein 4 | 0.560 |
HSPA1A | HSPA8 | ENSP00000364802 | ENSP00000227378 | heat shock 70kDa protein 1A | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.571 |
HSPA1A | SGTA | ENSP00000364802 | ENSP00000221566 | heat shock 70kDa protein 1A | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity | 0.679 |
HSPA1B | DNAJC5 | ENSP00000364801 | ENSP00000354111 | heat shock 70kDa protein 1B | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | 0.933 |
HSPA1B | HSPA4 | ENSP00000364801 | ENSP00000302961 | heat shock 70kDa protein 1B | heat shock 70kDa protein 4 | 0.549 |
HSPA1B | SGTA | ENSP00000364801 | ENSP00000221566 | heat shock 70kDa protein 1B | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity | 0.579 |
HSPA1L | DNAJC5 | ENSP00000364805 | ENSP00000354111 | heat shock 70kDa protein 1-like | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | 0.933 |
HSPA1L | HSPA4 | ENSP00000364805 | ENSP00000302961 | heat shock 70kDa protein 1-like | heat shock 70kDa protein 4 | 0.553 |
HSPA1L | SGTA | ENSP00000364805 | ENSP00000221566 | heat shock 70kDa protein 1-like | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity | 0.579 |