node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCL1 | NOTCH1 | ENSP00000266744 | ENSP00000277541 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.982 |
ASCL1 | OLIG2 | ENSP00000266744 | ENSP00000331040 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | oligodendrocyte lineage transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity) | 0.738 |
ASCL1 | PAX3 | ENSP00000266744 | ENSP00000375921 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | paired box 3 | 0.460 |
ASCL1 | SOX10 | ENSP00000266744 | ENSP00000354130 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) | 0.902 |
EDNRB | MITF | ENSP00000366416 | ENSP00000295600 | endothelin receptor type B | microphthalmia-associated transcription factor | 0.898 |
EDNRB | PAX3 | ENSP00000366416 | ENSP00000375921 | endothelin receptor type B | paired box 3 | 0.511 |
EDNRB | SOX10 | ENSP00000366416 | ENSP00000354130 | endothelin receptor type B | SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) | 0.945 |
EGR2 | FOXD3 | ENSP00000242480 | ENSP00000360157 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | 0.441 |
EGR2 | NFATC4 | ENSP00000242480 | ENSP00000388910 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 0.669 |
EGR2 | NOTCH1 | ENSP00000242480 | ENSP00000277541 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.415 |
EGR2 | PAX3 | ENSP00000242480 | ENSP00000375921 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | paired box 3 | 0.525 |
EGR2 | SOX10 | ENSP00000242480 | ENSP00000354130 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) | 0.960 |
FOXD3 | EGR2 | ENSP00000360157 | ENSP00000242480 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | 0.441 |
FOXD3 | MITF | ENSP00000360157 | ENSP00000295600 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | microphthalmia-associated transcription factor | 0.945 |
FOXD3 | PAX3 | ENSP00000360157 | ENSP00000375921 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | paired box 3 | 0.960 |
FOXD3 | SNAI2 | ENSP00000360157 | ENSP00000020945 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | snail homolog 2 (Drosophila); Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved [...] | 0.660 |
FOXD3 | SOX10 | ENSP00000360157 | ENSP00000354130 | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) | 0.976 |
MITF | EDNRB | ENSP00000295600 | ENSP00000366416 | microphthalmia-associated transcription factor | endothelin receptor type B | 0.898 |
MITF | FOXD3 | ENSP00000295600 | ENSP00000360157 | microphthalmia-associated transcription factor | forkhead box D3; Binds to the consensus sequence 5’-A[AT]T[AG]TTTGTTT-3’ and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis | 0.945 |
MITF | PAX3 | ENSP00000295600 | ENSP00000375921 | microphthalmia-associated transcription factor | paired box 3 | 0.985 |