| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BDNF | NGFR | ENSP00000414303 | ENSP00000172229 | brain-derived neurotrophic factor | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | 0.996 |
| BDNF | NTF3 | ENSP00000414303 | ENSP00000397297 | brain-derived neurotrophic factor | neurotrophin 3; Seems to promote the survival of visceral and proprioceptive sensory neurons | 0.996 |
| BDNF | NTF4 | ENSP00000414303 | ENSP00000301411 | brain-derived neurotrophic factor | neurotrophin 4; Target-derived survival factor for peripheral sensory sympathetic neurons | 0.971 |
| BDNF | NTRK3 | ENSP00000414303 | ENSP00000354207 | brain-derived neurotrophic factor | neurotrophic tyrosine kinase, receptor, type 3; Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties | 0.980 |
| BDNF | PLCG1 | ENSP00000414303 | ENSP00000244007 | brain-derived neurotrophic factor | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.985 |
| BDNF | SHC1 | ENSP00000414303 | ENSP00000401303 | brain-derived neurotrophic factor | SHC (Src homology 2 domain containing) transforming protein 1 | 0.951 |
| DOK5 | NTRK3 | ENSP00000262593 | ENSP00000354207 | docking protein 5; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation | neurotrophic tyrosine kinase, receptor, type 3; Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties | 0.926 |
| NGFR | BDNF | ENSP00000172229 | ENSP00000414303 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | brain-derived neurotrophic factor | 0.996 |
| NGFR | NTF3 | ENSP00000172229 | ENSP00000397297 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | neurotrophin 3; Seems to promote the survival of visceral and proprioceptive sensory neurons | 0.995 |
| NGFR | NTF4 | ENSP00000172229 | ENSP00000301411 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | neurotrophin 4; Target-derived survival factor for peripheral sensory sympathetic neurons | 0.986 |
| NGFR | NTRK3 | ENSP00000172229 | ENSP00000354207 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | neurotrophic tyrosine kinase, receptor, type 3; Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties | 0.935 |
| NGFR | PLCG1 | ENSP00000172229 | ENSP00000244007 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.922 |
| NGFR | SHC1 | ENSP00000172229 | ENSP00000401303 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | SHC (Src homology 2 domain containing) transforming protein 1 | 0.994 |
| NGFR | SHC4 | ENSP00000172229 | ENSP00000329668 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | SHC (Src homology 2 domain containing) family, member 4; Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1 | 0.896 |
| NTF3 | BDNF | ENSP00000397297 | ENSP00000414303 | neurotrophin 3; Seems to promote the survival of visceral and proprioceptive sensory neurons | brain-derived neurotrophic factor | 0.996 |
| NTF3 | NGFR | ENSP00000397297 | ENSP00000172229 | neurotrophin 3; Seems to promote the survival of visceral and proprioceptive sensory neurons | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | 0.995 |
| NTF3 | NTRK3 | ENSP00000397297 | ENSP00000354207 | neurotrophin 3; Seems to promote the survival of visceral and proprioceptive sensory neurons | neurotrophic tyrosine kinase, receptor, type 3; Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties | 0.999 |
| NTF3 | PLCG1 | ENSP00000397297 | ENSP00000244007 | neurotrophin 3; Seems to promote the survival of visceral and proprioceptive sensory neurons | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.918 |
| NTF3 | SHC1 | ENSP00000397297 | ENSP00000401303 | neurotrophin 3; Seems to promote the survival of visceral and proprioceptive sensory neurons | SHC (Src homology 2 domain containing) transforming protein 1 | 0.943 |
| NTF4 | BDNF | ENSP00000301411 | ENSP00000414303 | neurotrophin 4; Target-derived survival factor for peripheral sensory sympathetic neurons | brain-derived neurotrophic factor | 0.971 |
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