node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DLD | MPC1 | ENSP00000205402 | ENSP00000354223 | dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction | mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria | 0.903 |
DLD | MPC2 | ENSP00000205402 | ENSP00000271373 | dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction | mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria | 0.903 |
DLD | PDHA1 | ENSP00000205402 | ENSP00000369134 | dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction | pyruvate dehydrogenase (lipoamide) alpha 1 | 0.993 |
DLD | PDHB | ENSP00000205402 | ENSP00000307241 | dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction | pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.999 |
DLD | PDHX | ENSP00000205402 | ENSP00000227868 | dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction | pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex | 0.999 |
ITGA5 | MPC1 | ENSP00000293379 | ENSP00000354223 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria | 0.503 |
ME1 | MPC1 | ENSP00000358719 | ENSP00000354223 | malic enzyme 1, NADP(+)-dependent, cytosolic | mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria | 0.566 |
ME1 | PDHA1 | ENSP00000358719 | ENSP00000369134 | malic enzyme 1, NADP(+)-dependent, cytosolic | pyruvate dehydrogenase (lipoamide) alpha 1 | 0.925 |
ME1 | PDHB | ENSP00000358719 | ENSP00000307241 | malic enzyme 1, NADP(+)-dependent, cytosolic | pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.929 |
ME1 | PDHX | ENSP00000358719 | ENSP00000227868 | malic enzyme 1, NADP(+)-dependent, cytosolic | pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex | 0.430 |
ME2 | MPC1 | ENSP00000321070 | ENSP00000354223 | malic enzyme 2, NAD(+)-dependent, mitochondrial | mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria | 0.566 |
ME2 | PDHA1 | ENSP00000321070 | ENSP00000369134 | malic enzyme 2, NAD(+)-dependent, mitochondrial | pyruvate dehydrogenase (lipoamide) alpha 1 | 0.925 |
ME2 | PDHB | ENSP00000321070 | ENSP00000307241 | malic enzyme 2, NAD(+)-dependent, mitochondrial | pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.923 |
ME2 | PDHX | ENSP00000321070 | ENSP00000227868 | malic enzyme 2, NAD(+)-dependent, mitochondrial | pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex | 0.430 |
ME3 | MPC1 | ENSP00000352657 | ENSP00000354223 | malic enzyme 3, NADP(+)-dependent, mitochondrial | mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria | 0.566 |
ME3 | PDHA1 | ENSP00000352657 | ENSP00000369134 | malic enzyme 3, NADP(+)-dependent, mitochondrial | pyruvate dehydrogenase (lipoamide) alpha 1 | 0.925 |
ME3 | PDHB | ENSP00000352657 | ENSP00000307241 | malic enzyme 3, NADP(+)-dependent, mitochondrial | pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.926 |
ME3 | PDHX | ENSP00000352657 | ENSP00000227868 | malic enzyme 3, NADP(+)-dependent, mitochondrial | pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex | 0.430 |
MPC1 | DLD | ENSP00000354223 | ENSP00000205402 | mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria | dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction | 0.903 |
MPC1 | ITGA5 | ENSP00000354223 | ENSP00000293379 | mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | 0.503 |