node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPA1 | CTRB1 | ENSP00000011292 | ENSP00000354294 | carboxypeptidase A1 (pancreatic) | chymotrypsinogen B1 | 0.654 |
CTRB1 | CPA1 | ENSP00000354294 | ENSP00000011292 | chymotrypsinogen B1 | carboxypeptidase A1 (pancreatic) | 0.654 |
CTRB1 | GOT2 | ENSP00000354294 | ENSP00000245206 | chymotrypsinogen B1 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.655 |
CTRB1 | PGA3 | ENSP00000354294 | ENSP00000322192 | chymotrypsinogen B1 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.609 |
CTRB1 | PGA4 | ENSP00000354294 | ENSP00000367391 | chymotrypsinogen B1 | pepsinogen 4, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.644 |
CTRB1 | PGA5 | ENSP00000354294 | ENSP00000309542 | chymotrypsinogen B1 | pepsinogen 5, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.654 |
CTRB1 | SERPINA1 | ENSP00000354294 | ENSP00000348068 | chymotrypsinogen B1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.640 |
CTRB1 | SERPINA3 | ENSP00000354294 | ENSP00000376793 | chymotrypsinogen B1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.617 |
CTRB1 | SERPINF2 | ENSP00000354294 | ENSP00000321853 | chymotrypsinogen B1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | 0.619 |
CTRB1 | TAT | ENSP00000354294 | ENSP00000348234 | chymotrypsinogen B1 | tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine | 0.751 |
CTRB1 | TRH | ENSP00000354294 | ENSP00000303452 | chymotrypsinogen B1 | thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes | 0.801 |
GOT2 | CTRB1 | ENSP00000245206 | ENSP00000354294 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | chymotrypsinogen B1 | 0.655 |
GOT2 | TAT | ENSP00000245206 | ENSP00000348234 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine | 0.962 |
PGA3 | CTRB1 | ENSP00000322192 | ENSP00000354294 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | chymotrypsinogen B1 | 0.609 |
PGA4 | CTRB1 | ENSP00000367391 | ENSP00000354294 | pepsinogen 4, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | chymotrypsinogen B1 | 0.644 |
PGA5 | CTRB1 | ENSP00000309542 | ENSP00000354294 | pepsinogen 5, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | chymotrypsinogen B1 | 0.654 |
SERPINA1 | CTRB1 | ENSP00000348068 | ENSP00000354294 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | chymotrypsinogen B1 | 0.640 |
SERPINA1 | SERPINF2 | ENSP00000348068 | ENSP00000321853 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | 0.931 |
SERPINA3 | CTRB1 | ENSP00000376793 | ENSP00000354294 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | chymotrypsinogen B1 | 0.617 |
SERPINF2 | CTRB1 | ENSP00000321853 | ENSP00000354294 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | chymotrypsinogen B1 | 0.619 |