| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQR | PRPF8 | ENSP00000156471 | ENSP00000304350 | aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.678 |
| AQR | SNW1 | ENSP00000156471 | ENSP00000261531 | aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.433 |
| AQR | ZNF830 | ENSP00000156471 | ENSP00000354518 | aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.875 |
| FRA10AC1 | IK | ENSP00000360488 | ENSP00000396301 | fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 | IK cytokine, down-regulator of HLA II; May bind to chromatin | 0.710 |
| FRA10AC1 | ZNF830 | ENSP00000360488 | ENSP00000354518 | fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.815 |
| IK | FRA10AC1 | ENSP00000396301 | ENSP00000360488 | IK cytokine, down-regulator of HLA II; May bind to chromatin | fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 | 0.710 |
| IK | ZNF830 | ENSP00000396301 | ENSP00000354518 | IK cytokine, down-regulator of HLA II; May bind to chromatin | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.717 |
| ILF3 | ZNF830 | ENSP00000404121 | ENSP00000354518 | interleukin enhancer binding factor 3, 90kDa | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.702 |
| PCBP1 | PRPF8 | ENSP00000305556 | ENSP00000304350 | poly(rC) binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.974 |
| PCBP1 | ZNF830 | ENSP00000305556 | ENSP00000354518 | poly(rC) binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.741 |
| PPIL2 | ZNF830 | ENSP00000390427 | ENSP00000354518 | peptidylprolyl isomerase (cyclophilin)-like 2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.845 |
| PRPF8 | AQR | ENSP00000304350 | ENSP00000156471 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing | 0.678 |
| PRPF8 | PCBP1 | ENSP00000304350 | ENSP00000305556 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | poly(rC) binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | 0.974 |
| PRPF8 | SNW1 | ENSP00000304350 | ENSP00000261531 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.978 |
| PRPF8 | ZNF830 | ENSP00000304350 | ENSP00000354518 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.710 |
| SNW1 | AQR | ENSP00000261531 | ENSP00000156471 | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing | 0.433 |
| SNW1 | PRPF8 | ENSP00000261531 | ENSP00000304350 | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.978 |
| SNW1 | ZNF830 | ENSP00000261531 | ENSP00000354518 | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.750 |
| THOC5 | ZNF830 | ENSP00000380969 | ENSP00000354518 | THO complex 5; Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi’s sarcoma-associa [...] | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.759 |
| ZDHHC8 | ZNF830 | ENSP00000384716 | ENSP00000354518 | zinc finger, DHHC-type containing 8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1 | zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) | 0.707 |
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