node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD247 | CD3D | ENSP00000354782 | ENSP00000300692 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.985 |
CD247 | CD3E | ENSP00000354782 | ENSP00000354566 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.995 |
CD247 | CD3G | ENSP00000354782 | ENSP00000431445 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.972 |
CD247 | CSK | ENSP00000354782 | ENSP00000220003 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | c-src tyrosine kinase; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter p [...] | 0.983 |
CD247 | LAT | ENSP00000354782 | ENSP00000378845 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | linker for activation of T cells; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization [...] | 0.974 |
CD247 | LCK | ENSP00000354782 | ENSP00000337825 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | lymphocyte-specific protein tyrosine kinase | 0.999 |
CD247 | SHC1 | ENSP00000354782 | ENSP00000401303 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | SHC (Src homology 2 domain containing) transforming protein 1 | 0.982 |
CD247 | SYK | ENSP00000354782 | ENSP00000364898 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.944 |
CD247 | TRAT1 | ENSP00000354782 | ENSP00000295756 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.990 |
CD247 | ZAP70 | ENSP00000354782 | ENSP00000264972 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...] | 0.999 |
CD3D | CD247 | ENSP00000300692 | ENSP00000354782 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.985 |
CD3D | CD3E | ENSP00000300692 | ENSP00000354566 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.999 |
CD3D | CD3G | ENSP00000300692 | ENSP00000431445 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.965 |
CD3D | CSK | ENSP00000300692 | ENSP00000220003 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | c-src tyrosine kinase; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter p [...] | 0.900 |
CD3D | LAT | ENSP00000300692 | ENSP00000378845 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | linker for activation of T cells; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization [...] | 0.900 |
CD3D | LCK | ENSP00000300692 | ENSP00000337825 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | lymphocyte-specific protein tyrosine kinase | 0.924 |
CD3D | SHC1 | ENSP00000300692 | ENSP00000401303 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | SHC (Src homology 2 domain containing) transforming protein 1 | 0.900 |
CD3D | SYK | ENSP00000300692 | ENSP00000364898 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.912 |
CD3D | TRAT1 | ENSP00000300692 | ENSP00000295756 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.906 |
CD3D | ZAP70 | ENSP00000300692 | ENSP00000264972 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...] | 0.926 |