Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SFT2D1 | SFT2 domain containing 1; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) (159 aa) | ||||||||||||
Predicted Functional Partners:
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 | STX5 | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) (355 aa) |
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0.793 | |||||||||
 | GOLT1A | golgi transport 1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex (132 aa) |
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0.665 | ||||||||||
 | GOLT1B | golgi transport 1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex (138 aa) |
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0.665 | ||||||||||
 | PDE10A | phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (789 aa) |
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0.660 | ||||||||||
 | PACRG | PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (296 aa) |
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0.655 | ||||||||||
 | ALG6 | asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (507 aa) |
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0.586 | ||||||||||
 | SDIM1 | stress responsive DNAJB4 interacting membrane protein 1; Promotes neuronal cells survival to stress conditions (146 aa) |
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0.583 | ||||||||||
 | COG6 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa) |
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0.583 | ||||||||||
 | YKT6 | YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (198 aa) |
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0.579 | |||||||||
 | C6orf118 | chromosome 6 open reading frame 118 (469 aa) |
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0.568 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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