node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALU | IARS2 | ENSP00000420381 | ENSP00000303279 | calumenin | isoleucyl-tRNA synthetase 2, mitochondrial | 0.644 |
CALU | PPT2 | ENSP00000420381 | ENSP00000354608 | calumenin | palmitoyl-protein thioesterase 2 | 0.893 |
CALU | SARS2 | ENSP00000420381 | ENSP00000472847 | calumenin | seryl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) | 0.910 |
CDH2 | IARS2 | ENSP00000269141 | ENSP00000303279 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | isoleucyl-tRNA synthetase 2, mitochondrial | 0.891 |
CDH2 | MRPL23 | ENSP00000269141 | ENSP00000370930 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | mitochondrial ribosomal protein L23 | 0.567 |
CDH2 | MRPL49 | ENSP00000269141 | ENSP00000279242 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | mitochondrial ribosomal protein L49 | 0.898 |
CDH2 | MTHFD1 | ENSP00000269141 | ENSP00000450560 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.962 |
CDH2 | NENF | ENSP00000269141 | ENSP00000355955 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | neudesin neurotrophic factor; Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity) | 0.911 |
CDH2 | PC | ENSP00000269141 | ENSP00000377527 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate | 0.891 |
CDH2 | PPT2 | ENSP00000269141 | ENSP00000354608 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | palmitoyl-protein thioesterase 2 | 0.955 |
CDH2 | SARS2 | ENSP00000269141 | ENSP00000472847 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | seryl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) | 0.909 |
CDH2 | SUPT5H | ENSP00000269141 | ENSP00000404029 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.644 |
IARS2 | CALU | ENSP00000303279 | ENSP00000420381 | isoleucyl-tRNA synthetase 2, mitochondrial | calumenin | 0.644 |
IARS2 | CDH2 | ENSP00000303279 | ENSP00000269141 | isoleucyl-tRNA synthetase 2, mitochondrial | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | 0.891 |
IARS2 | MTHFD1 | ENSP00000303279 | ENSP00000450560 | isoleucyl-tRNA synthetase 2, mitochondrial | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.960 |
IARS2 | PPT2 | ENSP00000303279 | ENSP00000354608 | isoleucyl-tRNA synthetase 2, mitochondrial | palmitoyl-protein thioesterase 2 | 0.969 |
IARS2 | SARS2 | ENSP00000303279 | ENSP00000472847 | isoleucyl-tRNA synthetase 2, mitochondrial | seryl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) | 0.724 |
MRPL23 | CDH2 | ENSP00000370930 | ENSP00000269141 | mitochondrial ribosomal protein L23 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | 0.567 |
MRPL23 | MRPL49 | ENSP00000370930 | ENSP00000279242 | mitochondrial ribosomal protein L23 | mitochondrial ribosomal protein L49 | 0.949 |
MRPL23 | MTHFD1 | ENSP00000370930 | ENSP00000450560 | mitochondrial ribosomal protein L23 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.539 |