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ARAF ARAF KSR1 KSR1 RALA RALA RAF1 RAF1 RALGDS RALGDS CNKSR1 CNKSR1 CYTH3 CYTH3 RHOA RHOA RASSF1 RASSF1 RHPN2 RHPN2 RHPN1 RHPN1
"CNKSR1" - connector enhancer of kinase suppressor of Ras 1 in Homo sapiens
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Score
CNKSR1connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways (713 aa)    
Predicted Functional Partners:
RAF1
v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] (648 aa)
        score_image   score_image   0.991
RASSF1
Ras association (RalGDS/AF-6) domain family member 1 (344 aa)
        score_image   score_image   0.973
KSR1
kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity (923 aa)
        score_image   score_image   0.921
RALGDS
ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (914 aa)
        score_image   score_image   0.888
RHOA
ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] (193 aa)
        score_image   score_image   0.881
CYTH3
cytohesin 3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP (399 aa)
        score_image   score_image score_image 0.863
RHPN1
rhophilin, Rho GTPase binding protein 1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity) (670 aa)
        score_image   score_image   0.797
RALA
v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] (206 aa)
        score_image   score_image   0.790
RHPN2
rhophilin, Rho GTPase binding protein 2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (686 aa)
        score_image   score_image   0.742
ARAF
v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus (606 aa)
        score_image   score_image   0.733
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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