node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARAF | CNKSR1 | ENSP00000366244 | ENSP00000354609 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | 0.733 |
ARAF | KSR1 | ENSP00000366244 | ENSP00000323178 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | 0.719 |
ARAF | RAF1 | ENSP00000366244 | ENSP00000251849 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.587 |
ARAF | RALA | ENSP00000366244 | ENSP00000005257 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | 0.404 |
ARAF | RALGDS | ENSP00000366244 | ENSP00000361120 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap | 0.642 |
ARAF | RHOA | ENSP00000366244 | ENSP00000400175 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.482 |
CNKSR1 | ARAF | ENSP00000354609 | ENSP00000366244 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | 0.733 |
CNKSR1 | CYTH3 | ENSP00000354609 | ENSP00000297044 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | cytohesin 3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP | 0.863 |
CNKSR1 | KSR1 | ENSP00000354609 | ENSP00000323178 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | 0.921 |
CNKSR1 | RAF1 | ENSP00000354609 | ENSP00000251849 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.991 |
CNKSR1 | RALA | ENSP00000354609 | ENSP00000005257 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | 0.790 |
CNKSR1 | RALGDS | ENSP00000354609 | ENSP00000361120 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap | 0.888 |
CNKSR1 | RASSF1 | ENSP00000354609 | ENSP00000349547 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | Ras association (RalGDS/AF-6) domain family member 1 | 0.973 |
CNKSR1 | RHOA | ENSP00000354609 | ENSP00000400175 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.881 |
CNKSR1 | RHPN1 | ENSP00000354609 | ENSP00000289013 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | rhophilin, Rho GTPase binding protein 1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity) | 0.797 |
CNKSR1 | RHPN2 | ENSP00000354609 | ENSP00000254260 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | rhophilin, Rho GTPase binding protein 2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity | 0.742 |
CYTH3 | CNKSR1 | ENSP00000297044 | ENSP00000354609 | cytohesin 3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | 0.863 |
CYTH3 | RHOA | ENSP00000297044 | ENSP00000400175 | cytohesin 3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.924 |
KSR1 | ARAF | ENSP00000323178 | ENSP00000366244 | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | 0.719 |
KSR1 | CNKSR1 | ENSP00000323178 | ENSP00000354609 | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | 0.921 |