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STRINGSTRING
MPP1 MPP1 EPS8 EPS8 ESPN ESPN CASK CASK DFNB31 DFNB31 PCDH15 PCDH15 MYO15A MYO15A MYO7A MYO7A USH2A USH2A LRRC4C LRRC4C GPR98 GPR98
"DFNB31" - deafness, autosomal recessive 31 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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[Homology]
Score
DFNB31deafness, autosomal recessive 31 (907 aa)    
Predicted Functional Partners:
MYO15A
myosin XVA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity) (3530 aa)
        score_image   score_image   0.986
USH2A
Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision (5202 aa)
          score_image score_image   0.974
ESPN
espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity) (854 aa)
            score_image   0.913
EPS8
epidermal growth factor receptor pathway substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and ac [...] (822 aa)
            score_image   0.874
GPR98
G protein-coupled receptor 98; Receptor that may have an important role in the development of the central nervous system (6306 aa)
          score_image score_image   0.873
LRRC4C
leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons (640 aa)
        score_image   score_image   0.858
MPP1
membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) (466 aa)
            score_image   0.855
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
        score_image   score_image   0.826
PCDH15
protocadherin-related 15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function (1957 aa)
            score_image   0.813
MYO7A
myosin VIIA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphoge [...] (2215 aa)
        score_image   score_image   0.806
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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