node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASK | DFNB31 | ENSP00000367408 | ENSP00000354623 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | deafness, autosomal recessive 31 | 0.826 |
CASK | EPS8 | ENSP00000367408 | ENSP00000281172 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | epidermal growth factor receptor pathway substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and ac [...] | 0.906 |
DFNB31 | CASK | ENSP00000354623 | ENSP00000367408 | deafness, autosomal recessive 31 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.826 |
DFNB31 | EPS8 | ENSP00000354623 | ENSP00000281172 | deafness, autosomal recessive 31 | epidermal growth factor receptor pathway substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and ac [...] | 0.874 |
DFNB31 | ESPN | ENSP00000354623 | ENSP00000367059 | deafness, autosomal recessive 31 | espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity) | 0.913 |
DFNB31 | GPR98 | ENSP00000354623 | ENSP00000384582 | deafness, autosomal recessive 31 | G protein-coupled receptor 98; Receptor that may have an important role in the development of the central nervous system | 0.873 |
DFNB31 | LRRC4C | ENSP00000354623 | ENSP00000278198 | deafness, autosomal recessive 31 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | 0.858 |
DFNB31 | MPP1 | ENSP00000354623 | ENSP00000358547 | deafness, autosomal recessive 31 | membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) | 0.855 |
DFNB31 | MYO15A | ENSP00000354623 | ENSP00000205890 | deafness, autosomal recessive 31 | myosin XVA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity) | 0.986 |
DFNB31 | MYO7A | ENSP00000354623 | ENSP00000386331 | deafness, autosomal recessive 31 | myosin VIIA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphoge [...] | 0.806 |
DFNB31 | PCDH15 | ENSP00000354623 | ENSP00000354950 | deafness, autosomal recessive 31 | protocadherin-related 15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function | 0.813 |
DFNB31 | USH2A | ENSP00000354623 | ENSP00000305941 | deafness, autosomal recessive 31 | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision | 0.974 |
EPS8 | CASK | ENSP00000281172 | ENSP00000367408 | epidermal growth factor receptor pathway substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and ac [...] | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.906 |
EPS8 | DFNB31 | ENSP00000281172 | ENSP00000354623 | epidermal growth factor receptor pathway substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and ac [...] | deafness, autosomal recessive 31 | 0.874 |
EPS8 | MPP1 | ENSP00000281172 | ENSP00000358547 | epidermal growth factor receptor pathway substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and ac [...] | membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) | 0.572 |
EPS8 | MYO15A | ENSP00000281172 | ENSP00000205890 | epidermal growth factor receptor pathway substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and ac [...] | myosin XVA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity) | 0.875 |
ESPN | DFNB31 | ENSP00000367059 | ENSP00000354623 | espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity) | deafness, autosomal recessive 31 | 0.913 |
ESPN | MYO15A | ENSP00000367059 | ENSP00000205890 | espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity) | myosin XVA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity) | 0.663 |
ESPN | MYO7A | ENSP00000367059 | ENSP00000386331 | espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity) | myosin VIIA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphoge [...] | 0.431 |
ESPN | PCDH15 | ENSP00000367059 | ENSP00000354950 | espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity) | protocadherin-related 15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function | 0.568 |