| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DIO1 | GPBAR1 | ENSP00000354643 | ENSP00000428824 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | 0.751 |
| DIO1 | NKX2-1 | ENSP00000354643 | ENSP00000346879 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | 0.400 |
| DIO1 | NR1H4 | ENSP00000354643 | ENSP00000447149 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.404 |
| DIO1 | PAX8 | ENSP00000354643 | ENSP00000395498 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | paired box 8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells | 0.487 |
| DIO1 | SELT | ENSP00000354643 | ENSP00000418910 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | selenoprotein T precursor | 0.493 |
| DIO1 | SRPK2 | ENSP00000354643 | ENSP00000377262 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.461 |
| DIO1 | THRB | ENSP00000354643 | ENSP00000348827 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.418 |
| DIO1 | TRH | ENSP00000354643 | ENSP00000303452 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes | 0.510 |
| DIO1 | TSHR | ENSP00000354643 | ENSP00000298171 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | thyroid stimulating hormone receptor | 0.457 |
| DIO1 | VIMP | ENSP00000354643 | ENSP00000381282 | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination | 0.606 |
| GPBAR1 | DIO1 | ENSP00000428824 | ENSP00000354643 | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | 0.751 |
| GPBAR1 | NKX2-1 | ENSP00000428824 | ENSP00000346879 | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | 0.440 |
| GPBAR1 | NR1H4 | ENSP00000428824 | ENSP00000447149 | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.681 |
| GPBAR1 | PAX8 | ENSP00000428824 | ENSP00000395498 | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | paired box 8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells | 0.560 |
| GPBAR1 | TSHR | ENSP00000428824 | ENSP00000298171 | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | thyroid stimulating hormone receptor | 0.900 |
| GPBAR1 | VIMP | ENSP00000428824 | ENSP00000381282 | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination | 0.654 |
| NKX2-1 | DIO1 | ENSP00000346879 | ENSP00000354643 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | deiodinase, iodothyronine, type I; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) (By similarity) | 0.400 |
| NKX2-1 | GPBAR1 | ENSP00000346879 | ENSP00000428824 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | G protein-coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | 0.440 |
| NKX2-1 | PAX8 | ENSP00000346879 | ENSP00000395498 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | paired box 8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells | 0.992 |
| NKX2-1 | TSHR | ENSP00000346879 | ENSP00000298171 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | thyroid stimulating hormone receptor | 0.941 |
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