FAM63A protein (Homo sapiens) - STRING network view

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FAM63A

family with sequence similarity 63, member A (517 aa)

Predicted Functional Partners:

TLR4

0.793

ATM

0.793

PTK2

0.791

USP28

0.780

UBC

0.752

USP25

0.678

ZNF629

0.670

PTK2B

0.604

PRDM10

0.597

VMP1

0.592

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	FAM63A	ENSP00000278616	ENSP00000354669	ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and [...]	family with sequence similarity 63, member A	0.793
ATM	PRDM10	ENSP00000278616	ENSP00000351686	ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and [...]	PR domain containing 10	0.635
ATM	UBC	ENSP00000278616	ENSP00000344818	ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and [...]	ubiquitin C	0.836
FAM63A	ATM	ENSP00000354669	ENSP00000278616	family with sequence similarity 63, member A	ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and [...]	0.793
FAM63A	PRDM10	ENSP00000354669	ENSP00000351686	family with sequence similarity 63, member A	PR domain containing 10	0.597
FAM63A	PTK2	ENSP00000354669	ENSP00000341189	family with sequence similarity 63, member A	PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...]	0.791
FAM63A	PTK2B	ENSP00000354669	ENSP00000332816	family with sequence similarity 63, member A	PTK2B protein tyrosine kinase 2 beta; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T- cells, and contributes to the regulation of T-cell responses. [...]	0.604
FAM63A	TLR4	ENSP00000354669	ENSP00000363089	family with sequence similarity 63, member A	toll-like receptor 4	0.793
FAM63A	UBC	ENSP00000354669	ENSP00000344818	family with sequence similarity 63, member A	ubiquitin C	0.752
FAM63A	USP25	ENSP00000354669	ENSP00000285679	family with sequence similarity 63, member A	ubiquitin specific peptidase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains	0.678
FAM63A	USP28	ENSP00000354669	ENSP00000003302	family with sequence similarity 63, member A	ubiquitin specific peptidase 28; Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome- acts by specifically interacting wit [...]	0.780
FAM63A	VMP1	ENSP00000354669	ENSP00000262291	family with sequence similarity 63, member A	vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions	0.592
FAM63A	ZNF629	ENSP00000354669	ENSP00000262525	family with sequence similarity 63, member A	zinc finger protein 629; May be involved in transcriptional regulation	0.670
PRDM10	ATM	ENSP00000351686	ENSP00000278616	PR domain containing 10	ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and [...]	0.635
PRDM10	FAM63A	ENSP00000351686	ENSP00000354669	PR domain containing 10	family with sequence similarity 63, member A	0.597
PRDM10	PTK2	ENSP00000351686	ENSP00000341189	PR domain containing 10	PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...]	0.632
PRDM10	PTK2B	ENSP00000351686	ENSP00000332816	PR domain containing 10	PTK2B protein tyrosine kinase 2 beta; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T- cells, and contributes to the regulation of T-cell responses. [...]	0.508
PRDM10	TLR4	ENSP00000351686	ENSP00000363089	PR domain containing 10	toll-like receptor 4	0.595
PRDM10	UBC	ENSP00000351686	ENSP00000344818	PR domain containing 10	ubiquitin C	0.562
PRDM10	VMP1	ENSP00000351686	ENSP00000262291	PR domain containing 10	vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions	0.637

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