node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCORL1 | CAB39 | ENSP00000218147 | ENSP00000258418 | BCL6 corepressor-like 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor | calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | 0.525 |
BCORL1 | DET1 | ENSP00000218147 | ENSP00000408994 | BCL6 corepressor-like 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor | de-etiolated homolog 1 (Arabidopsis); Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | 0.615 |
BCORL1 | ZNF652 | ENSP00000218147 | ENSP00000354686 | BCL6 corepressor-like 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor | zinc finger protein 652; Functions as a transcriptional repressor | 0.628 |
C10orf107 | PLCD3 | ENSP00000328698 | ENSP00000313731 | chromosome 10 open reading frame 107 | phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow | 0.708 |
C10orf107 | ZNF652 | ENSP00000328698 | ENSP00000354686 | chromosome 10 open reading frame 107 | zinc finger protein 652; Functions as a transcriptional repressor | 0.634 |
CAB39 | BCORL1 | ENSP00000258418 | ENSP00000218147 | calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | BCL6 corepressor-like 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor | 0.525 |
CAB39 | DET1 | ENSP00000258418 | ENSP00000408994 | calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | de-etiolated homolog 1 (Arabidopsis); Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | 0.411 |
CAB39 | ZNF652 | ENSP00000258418 | ENSP00000354686 | calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | zinc finger protein 652; Functions as a transcriptional repressor | 0.537 |
CBFA2T2 | CBFA2T3 | ENSP00000262653 | ENSP00000268679 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | 0.585 |
CBFA2T2 | RUNX1T1 | ENSP00000262653 | ENSP00000402257 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.945 |
CBFA2T2 | ZNF652 | ENSP00000262653 | ENSP00000354686 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | zinc finger protein 652; Functions as a transcriptional repressor | 0.596 |
CBFA2T3 | CBFA2T2 | ENSP00000268679 | ENSP00000262653 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.585 |
CBFA2T3 | DET1 | ENSP00000268679 | ENSP00000408994 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | de-etiolated homolog 1 (Arabidopsis); Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | 0.405 |
CBFA2T3 | RUNX1T1 | ENSP00000268679 | ENSP00000402257 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.812 |
CBFA2T3 | ZNF652 | ENSP00000268679 | ENSP00000354686 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | zinc finger protein 652; Functions as a transcriptional repressor | 0.944 |
DET1 | BCORL1 | ENSP00000408994 | ENSP00000218147 | de-etiolated homolog 1 (Arabidopsis); Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | BCL6 corepressor-like 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor | 0.615 |
DET1 | CAB39 | ENSP00000408994 | ENSP00000258418 | de-etiolated homolog 1 (Arabidopsis); Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | calcium binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | 0.411 |
DET1 | CBFA2T3 | ENSP00000408994 | ENSP00000268679 | de-etiolated homolog 1 (Arabidopsis); Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | 0.405 |
DET1 | ZNF652 | ENSP00000408994 | ENSP00000354686 | de-etiolated homolog 1 (Arabidopsis); Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | zinc finger protein 652; Functions as a transcriptional repressor | 0.573 |
PDP2 | ZNF652 | ENSP00000309548 | ENSP00000354686 | pyruvate dehyrogenase phosphatase catalytic subunit 2; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | zinc finger protein 652; Functions as a transcriptional repressor | 0.609 |