| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AVL9 | DENND6A | ENSP00000315568 | ENSP00000311401 | AVL9 homolog (S. cerevisiase); Functions in cell migration | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | 0.861 |
| AVL9 | FAM45A | ENSP00000315568 | ENSP00000354688 | AVL9 homolog (S. cerevisiase); Functions in cell migration | family with sequence similarity 45, member A | 0.861 |
| AVL9 | KIAA1147 | ENSP00000315568 | ENSP00000445768 | AVL9 homolog (S. cerevisiase); Functions in cell migration | KIAA1147; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity) | 0.872 |
| DENND6A | AVL9 | ENSP00000311401 | ENSP00000315568 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | AVL9 homolog (S. cerevisiase); Functions in cell migration | 0.861 |
| DENND6A | FAM45A | ENSP00000311401 | ENSP00000354688 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | family with sequence similarity 45, member A | 0.864 |
| DENND6A | KIAA1147 | ENSP00000311401 | ENSP00000445768 | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | KIAA1147; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity) | 0.868 |
| EIF4EBP2 | FAM45A | ENSP00000362314 | ENSP00000354688 | eukaryotic translation initiation factor 4E binding protein 2; Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway | family with sequence similarity 45, member A | 0.457 |
| FAM21A | FAM21B | ENSP00000282633 | ENSP00000351259 | family with sequence similarity 21, member A; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | family with sequence similarity 21, member B; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | 0.720 |
| FAM21A | FAM21D | ENSP00000282633 | ENSP00000309786 | family with sequence similarity 21, member A; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | family with sequence similarity 21, member D | 0.720 |
| FAM21A | FAM45A | ENSP00000282633 | ENSP00000354688 | family with sequence similarity 21, member A; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | family with sequence similarity 45, member A | 0.451 |
| FAM21B | FAM21A | ENSP00000351259 | ENSP00000282633 | family with sequence similarity 21, member B; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | family with sequence similarity 21, member A; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | 0.720 |
| FAM21B | FAM21D | ENSP00000351259 | ENSP00000309786 | family with sequence similarity 21, member B; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | family with sequence similarity 21, member D | 0.720 |
| FAM21B | FAM45A | ENSP00000351259 | ENSP00000354688 | family with sequence similarity 21, member B; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | family with sequence similarity 45, member A | 0.451 |
| FAM21C | FAM45A | ENSP00000363482 | ENSP00000354688 | family with sequence similarity 21, member C | family with sequence similarity 45, member A | 0.451 |
| FAM21D | FAM21A | ENSP00000309786 | ENSP00000282633 | family with sequence similarity 21, member D | family with sequence similarity 21, member A; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | 0.720 |
| FAM21D | FAM21B | ENSP00000309786 | ENSP00000351259 | family with sequence similarity 21, member D | family with sequence similarity 21, member B; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity) | 0.720 |
| FAM21D | FAM45A | ENSP00000309786 | ENSP00000354688 | family with sequence similarity 21, member D | family with sequence similarity 45, member A | 0.451 |
| FAM45A | AVL9 | ENSP00000354688 | ENSP00000315568 | family with sequence similarity 45, member A | AVL9 homolog (S. cerevisiase); Functions in cell migration | 0.861 |
| FAM45A | DENND6A | ENSP00000354688 | ENSP00000311401 | family with sequence similarity 45, member A | DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes | 0.864 |
| FAM45A | EIF4EBP2 | ENSP00000354688 | ENSP00000362314 | family with sequence similarity 45, member A | eukaryotic translation initiation factor 4E binding protein 2; Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway | 0.457 |
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