node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FOXI1 | NALCN | ENSP00000304286 | ENSP00000251127 | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | sodium leak channel, non-selective; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity) | 0.457 |
FOXI1 | SLC26A1 | ENSP00000304286 | ENSP00000354721 | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 0.511 |
FOXI1 | SLC4A4 | ENSP00000304286 | ENSP00000393557 | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.474 |
NALCN | FOXI1 | ENSP00000251127 | ENSP00000304286 | sodium leak channel, non-selective; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity) | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | 0.457 |
NALCN | SLC26A1 | ENSP00000251127 | ENSP00000354721 | sodium leak channel, non-selective; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity) | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 0.538 |
PAPSS1 | PAPSS2 | ENSP00000265174 | ENSP00000406157 | 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the [...] | 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] | 0.998 |
PAPSS1 | SLC26A1 | ENSP00000265174 | ENSP00000354721 | 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the [...] | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 0.947 |
PAPSS2 | PAPSS1 | ENSP00000406157 | ENSP00000265174 | 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] | 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the [...] | 0.998 |
PAPSS2 | SLC13A1 | ENSP00000406157 | ENSP00000194130 | 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] | solute carrier family 13 (sodium/sulfate symporters), member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney | 0.432 |
PAPSS2 | SLC26A1 | ENSP00000406157 | ENSP00000354721 | 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 0.962 |
SLC13A1 | PAPSS2 | ENSP00000194130 | ENSP00000406157 | solute carrier family 13 (sodium/sulfate symporters), member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney | 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] | 0.432 |
SLC13A1 | SLC26A1 | ENSP00000194130 | ENSP00000354721 | solute carrier family 13 (sodium/sulfate symporters), member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 0.755 |
SLC13A1 | SLC4A4 | ENSP00000194130 | ENSP00000393557 | solute carrier family 13 (sodium/sulfate symporters), member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.405 |
SLC13A4 | SLC26A1 | ENSP00000297282 | ENSP00000354721 | solute carrier family 13 (sodium/sulfate symporters), member 4; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV) | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 0.518 |
SLC26A1 | FOXI1 | ENSP00000354721 | ENSP00000304286 | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | 0.511 |
SLC26A1 | NALCN | ENSP00000354721 | ENSP00000251127 | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | sodium leak channel, non-selective; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity) | 0.538 |
SLC26A1 | PAPSS1 | ENSP00000354721 | ENSP00000265174 | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the [...] | 0.947 |
SLC26A1 | PAPSS2 | ENSP00000354721 | ENSP00000406157 | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] | 0.962 |
SLC26A1 | SLC13A1 | ENSP00000354721 | ENSP00000194130 | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | solute carrier family 13 (sodium/sulfate symporters), member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney | 0.755 |
SLC26A1 | SLC13A4 | ENSP00000354721 | ENSP00000297282 | solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate | solute carrier family 13 (sodium/sulfate symporters), member 4; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV) | 0.518 |