SPRYD7 protein (Homo sapiens) - STRING network view

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Score

SPRYD7

SPRY domain containing 7 (196 aa)

Predicted Functional Partners:

UBC

0.857

SETDB2

0.822

RCBTB1

0.807

TRIM13

0.768

MEIG1

0.659

CCDC122

0.610

LACC1

0.610

DLEU1

0.582

NOBOX

0.560

HERC1

0.541

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC122	LACC1	ENSP00000407763	ENSP00000317619	coiled-coil domain containing 122	laccase (multicopper oxidoreductase) domain containing 1	0.779
CCDC122	NOBOX	ENSP00000407763	ENSP00000419457	coiled-coil domain containing 122	NOBOX oogenesis homeobox; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’ (By similarity)	0.518
CCDC122	SPRYD7	ENSP00000407763	ENSP00000354774	coiled-coil domain containing 122	SPRY domain containing 7	0.610
DLEU1	SETDB2	ENSP00000367422	ENSP00000326477	deleted in lymphocytic leukemia 1 (non-protein coding); May act as a tumor suppressor	SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis	0.453
DLEU1	SPRYD7	ENSP00000367422	ENSP00000354774	deleted in lymphocytic leukemia 1 (non-protein coding); May act as a tumor suppressor	SPRY domain containing 7	0.582
DLEU1	TRIM13	ENSP00000367422	ENSP00000298772	deleted in lymphocytic leukemia 1 (non-protein coding); May act as a tumor suppressor	tripartite motif containing 13; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor	0.748
HERC1	MEIG1	ENSP00000390158	ENSP00000367486	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates	meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity)	0.452
HERC1	SPRYD7	ENSP00000390158	ENSP00000354774	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates	SPRY domain containing 7	0.541
HERC1	UBC	ENSP00000390158	ENSP00000344818	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates	ubiquitin C	0.948
LACC1	CCDC122	ENSP00000317619	ENSP00000407763	laccase (multicopper oxidoreductase) domain containing 1	coiled-coil domain containing 122	0.779
LACC1	NOBOX	ENSP00000317619	ENSP00000419457	laccase (multicopper oxidoreductase) domain containing 1	NOBOX oogenesis homeobox; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’ (By similarity)	0.520
LACC1	SPRYD7	ENSP00000317619	ENSP00000354774	laccase (multicopper oxidoreductase) domain containing 1	SPRY domain containing 7	0.610
MEIG1	HERC1	ENSP00000367486	ENSP00000390158	meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity)	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates	0.452
MEIG1	SPRYD7	ENSP00000367486	ENSP00000354774	meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity)	SPRY domain containing 7	0.659
NOBOX	CCDC122	ENSP00000419457	ENSP00000407763	NOBOX oogenesis homeobox; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’ (By similarity)	coiled-coil domain containing 122	0.518
NOBOX	LACC1	ENSP00000419457	ENSP00000317619	NOBOX oogenesis homeobox; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’ (By similarity)	laccase (multicopper oxidoreductase) domain containing 1	0.520
NOBOX	SPRYD7	ENSP00000419457	ENSP00000354774	NOBOX oogenesis homeobox; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’ (By similarity)	SPRY domain containing 7	0.560
RCBTB1	SETDB2	ENSP00000258646	ENSP00000326477	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling	SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis	0.775
RCBTB1	SPRYD7	ENSP00000258646	ENSP00000354774	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling	SPRY domain containing 7	0.807
SETDB2	DLEU1	ENSP00000326477	ENSP00000367422	SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis	deleted in lymphocytic leukemia 1 (non-protein coding); May act as a tumor suppressor	0.453

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