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STRINGSTRING
OBSL1 OBSL1 APBA3 APBA3 AZI2 AZI2 TBKBP1 TBKBP1 TANK TANK RB1CC1 RB1CC1 UBC UBC CALCOCO2 CALCOCO2 TBK1 TBK1 EIF2C2 EIF2C2 FXR2 FXR2
"TBKBP1" - TBK1 binding protein 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
TBKBP1TBK1 binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity (By similarity) (615 aa)    
Predicted Functional Partners:
TBK1
TANK-binding kinase 1; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFN- alpha and IFN-beta. In order to establish such an antiviral state, TBK1 form severa [...] (729 aa)
        score_image   score_image   0.993
CALCOCO2
calcium binding and coiled-coil domain 2; May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion (446 aa)
        score_image   score_image   0.920
AZI2
5-azacytidine induced 2; Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1 (392 aa)
        score_image score_image score_image score_image 0.919
TANK
TRAF family member-associated NFKB activator; Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity (425 aa)
          score_image score_image   0.903
UBC
ubiquitin C (685 aa)
        score_image       0.686
EIF2C2
eukaryotic translation initiation factor 2C, 2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The ’minimal RISC’ appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC- mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due [...] (859 aa)
        score_image       0.670
FXR2
fragile X mental retardation, autosomal homolog 2; RNA-binding protein (673 aa)
        score_image       0.634
RB1CC1
RB1-inducible coiled-coil 1; Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensib [...] (1594 aa)
        score_image   score_image   0.464
APBA3
amyloid beta (A4) precursor protein-binding, family A, member 3; May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (575 aa)
        score_image       0.459
OBSL1
obscurin-like 1; Regulates CUL7-FBXW8-containing ubiquitin ligase complex, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Localizes CUL7 to the Golgi apparatus in neurons (1896 aa)
        score_image       0.452
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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