CD247 protein (Homo sapiens) - STRING network view

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CD247

CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering (164 aa)

Predicted Functional Partners:

ZAP70

0.999

LCK

0.999

CD3E

0.995

TRAT1

0.990

CD3D

0.985

CSK

0.983

SHC1

0.982

FYN

0.975

LAT

0.974

CD2

0.972

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD2	CD247	ENSP00000358490	ENSP00000354782	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	0.972
CD2	CD3D	ENSP00000358490	ENSP00000300692	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	0.454
CD2	CD3E	ENSP00000358490	ENSP00000354566	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.435
CD2	FYN	ENSP00000358490	ENSP00000346671	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	0.694
CD2	LCK	ENSP00000358490	ENSP00000337825	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	lymphocyte-specific protein tyrosine kinase	0.979
CD2	ZAP70	ENSP00000358490	ENSP00000264972	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...]	0.414
CD247	CD2	ENSP00000354782	ENSP00000358490	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	0.972
CD247	CD3D	ENSP00000354782	ENSP00000300692	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	0.985
CD247	CD3E	ENSP00000354782	ENSP00000354566	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.995
CD247	CSK	ENSP00000354782	ENSP00000220003	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	c-src tyrosine kinase; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter p [...]	0.983
CD247	FYN	ENSP00000354782	ENSP00000346671	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	0.975
CD247	LAT	ENSP00000354782	ENSP00000378845	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	linker for activation of T cells; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization [...]	0.974
CD247	LCK	ENSP00000354782	ENSP00000337825	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	lymphocyte-specific protein tyrosine kinase	0.999
CD247	SHC1	ENSP00000354782	ENSP00000401303	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	SHC (Src homology 2 domain containing) transforming protein 1	0.982
CD247	TRAT1	ENSP00000354782	ENSP00000295756	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells	0.990
CD247	ZAP70	ENSP00000354782	ENSP00000264972	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...]	0.999
CD3D	CD2	ENSP00000300692	ENSP00000358490	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function	0.454
CD3D	CD247	ENSP00000300692	ENSP00000354782	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	0.985
CD3D	CD3E	ENSP00000300692	ENSP00000354566	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.999
CD3D	CSK	ENSP00000300692	ENSP00000220003	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	c-src tyrosine kinase; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter p [...]	0.900

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