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STRINGSTRING
CLIP1 CLIP1 ACTR1A ACTR1A MAPRE1 MAPRE1 PAFAH1B1 PAFAH1B1 DYNC1I2 DYNC1I2 DCTN2 DCTN2 DCTN3 DCTN3 ACTR1B ACTR1B DCTN1 DCTN1 DYNC1H1 DYNC1H1 RANBP9 RANBP9
"DCTN1" - dynactin 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
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protein homology
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Score
DCTN1dynactin 1 (1278 aa)    
Predicted Functional Partners:
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (4646 aa)
      score_image score_image score_image score_image   0.999
CLIP1
CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking (1427 aa)
        score_image score_image score_image score_image 0.999
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)
      score_image score_image score_image score_image   0.999
DCTN2
dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (406 aa)
      score_image score_image score_image score_image   0.998
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)
      score_image score_image score_image score_image   0.998
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] (410 aa)
        score_image score_image score_image   0.995
MAPRE1
microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (268 aa)
        score_image   score_image   0.992
DCTN3
dynactin 3 (p22); Together with dynein may be involved in spindle assembly and cytokinesis (186 aa)
        score_image score_image score_image   0.989
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2 (638 aa)
      score_image score_image score_image score_image   0.983
RANBP9
RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] (729 aa)
        score_image   score_image   0.975
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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