node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD14B | ALAS1 | ENSP00000354841 | ENSP00000309259 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | aminolevulinate, delta-, synthase 1 | 0.601 |
ABHD14B | ALAS2 | ENSP00000354841 | ENSP00000332369 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | aminolevulinate, delta-, synthase 2 | 0.601 |
ABHD14B | GCAT | ENSP00000354841 | ENSP00000371110 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | glycine C-acetyltransferase | 0.601 |
ABHD14B | ITGA2 | ENSP00000354841 | ENSP00000296585 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.569 |
ABHD14B | PPWD1 | ENSP00000354841 | ENSP00000261308 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | peptidylprolyl isomerase domain and WD repeat containing 1; Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing | 0.597 |
ABHD14B | PSEN2 | ENSP00000354841 | ENSP00000355747 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | presenilin 2 (Alzheimer disease 4); Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins | 0.566 |
ABHD14B | SPTLC1 | ENSP00000354841 | ENSP00000262554 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...] | 0.601 |
ABHD14B | SPTLC2 | ENSP00000354841 | ENSP00000216484 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate | 0.601 |
ABHD14B | SPTLC3 | ENSP00000354841 | ENSP00000381968 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.601 |
ABHD14B | WASL | ENSP00000354841 | ENSP00000223023 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression | 0.569 |
ALAS1 | ABHD14B | ENSP00000309259 | ENSP00000354841 | aminolevulinate, delta-, synthase 1 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | 0.601 |
ALAS1 | ALAS2 | ENSP00000309259 | ENSP00000332369 | aminolevulinate, delta-, synthase 1 | aminolevulinate, delta-, synthase 2 | 0.807 |
ALAS1 | GCAT | ENSP00000309259 | ENSP00000371110 | aminolevulinate, delta-, synthase 1 | glycine C-acetyltransferase | 0.912 |
ALAS2 | ABHD14B | ENSP00000332369 | ENSP00000354841 | aminolevulinate, delta-, synthase 2 | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | 0.601 |
ALAS2 | ALAS1 | ENSP00000332369 | ENSP00000309259 | aminolevulinate, delta-, synthase 2 | aminolevulinate, delta-, synthase 1 | 0.807 |
ALAS2 | GCAT | ENSP00000332369 | ENSP00000371110 | aminolevulinate, delta-, synthase 2 | glycine C-acetyltransferase | 0.909 |
GCAT | ABHD14B | ENSP00000371110 | ENSP00000354841 | glycine C-acetyltransferase | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | 0.601 |
GCAT | ALAS1 | ENSP00000371110 | ENSP00000309259 | glycine C-acetyltransferase | aminolevulinate, delta-, synthase 1 | 0.912 |
GCAT | ALAS2 | ENSP00000371110 | ENSP00000332369 | glycine C-acetyltransferase | aminolevulinate, delta-, synthase 2 | 0.909 |
ITGA2 | ABHD14B | ENSP00000296585 | ENSP00000354841 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription | 0.569 |