| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CA8 | SDCBP | ENSP00000314407 | ENSP00000260130 | carbonic anhydrase VIII; Does not have a carbonic anhydrase catalytic activity | syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway | 0.606 |
| CA8 | TOX | ENSP00000314407 | ENSP00000354842 | carbonic anhydrase VIII; Does not have a carbonic anhydrase catalytic activity | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.606 |
| CCR6 | TOX | ENSP00000339393 | ENSP00000354842 | chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.567 |
| H2AFV | SUPT16H | ENSP00000308405 | ENSP00000216297 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | suppressor of Ty 16 homolog (S. cerevisiae); Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the [...] | 0.957 |
| H2AFV | TOP2A | ENSP00000308405 | ENSP00000411532 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | topoisomerase (DNA) II alpha 170kDa | 0.792 |
| H2AFV | TOX | ENSP00000308405 | ENSP00000354842 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.566 |
| SDCBP | CA8 | ENSP00000260130 | ENSP00000314407 | syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway | carbonic anhydrase VIII; Does not have a carbonic anhydrase catalytic activity | 0.606 |
| SDCBP | TOX | ENSP00000260130 | ENSP00000354842 | syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.602 |
| SLC25A5 | TOX | ENSP00000360671 | ENSP00000354842 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.681 |
| SLC25A6 | TOX | ENSP00000370808 | ENSP00000354842 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.749 |
| SUPT16H | H2AFV | ENSP00000216297 | ENSP00000308405 | suppressor of Ty 16 homolog (S. cerevisiae); Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the [...] | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.957 |
| SUPT16H | TOP2A | ENSP00000216297 | ENSP00000411532 | suppressor of Ty 16 homolog (S. cerevisiae); Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the [...] | topoisomerase (DNA) II alpha 170kDa | 0.658 |
| SUPT16H | TOX | ENSP00000216297 | ENSP00000354842 | suppressor of Ty 16 homolog (S. cerevisiae); Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the [...] | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.651 |
| TBX21 | TOX | ENSP00000177694 | ENSP00000354842 | T-box 21; Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.814 |
| TOP2A | H2AFV | ENSP00000411532 | ENSP00000308405 | topoisomerase (DNA) II alpha 170kDa | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.792 |
| TOP2A | SUPT16H | ENSP00000411532 | ENSP00000216297 | topoisomerase (DNA) II alpha 170kDa | suppressor of Ty 16 homolog (S. cerevisiae); Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the [...] | 0.658 |
| TOP2A | TOX | ENSP00000411532 | ENSP00000354842 | topoisomerase (DNA) II alpha 170kDa | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | 0.581 |
| TOX | CA8 | ENSP00000354842 | ENSP00000314407 | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | carbonic anhydrase VIII; Does not have a carbonic anhydrase catalytic activity | 0.606 |
| TOX | CCR6 | ENSP00000354842 | ENSP00000339393 | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level | 0.567 |
| TOX | H2AFV | ENSP00000354842 | ENSP00000308405 | thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.566 |
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