node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYBPC1 | MYH14 | ENSP00000354849 | ENSP00000262269 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 14, non-muscle | 0.938 |
MYBPC1 | MYH3 | ENSP00000354849 | ENSP00000226209 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | 0.959 |
MYBPC1 | MYH6 | ENSP00000354849 | ENSP00000348634 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.929 |
MYBPC1 | MYH8 | ENSP00000354849 | ENSP00000384330 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.929 |
MYBPC1 | NEB | ENSP00000354849 | ENSP00000380505 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | nebulin | 0.931 |
MYBPC1 | TNNI1 | ENSP00000354849 | ENSP00000337022 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin I type 1 (skeletal, slow) | 0.928 |
MYBPC1 | TNNI2 | ENSP00000354849 | ENSP00000252898 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.938 |
MYBPC1 | TNNT3 | ENSP00000354849 | ENSP00000278317 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin T type 3 (skeletal, fast) | 0.946 |
MYBPC1 | TPM2 | ENSP00000354849 | ENSP00000354219 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.929 |
MYBPC1 | TTN | ENSP00000354849 | ENSP00000343764 | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | titin | 0.969 |
MYH14 | MYBPC1 | ENSP00000262269 | ENSP00000354849 | myosin, heavy chain 14, non-muscle | myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | 0.938 |
MYH14 | MYH3 | ENSP00000262269 | ENSP00000226209 | myosin, heavy chain 14, non-muscle | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | 0.740 |
MYH14 | MYH6 | ENSP00000262269 | ENSP00000348634 | myosin, heavy chain 14, non-muscle | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.750 |
MYH14 | MYH8 | ENSP00000262269 | ENSP00000384330 | myosin, heavy chain 14, non-muscle | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.739 |
MYH14 | NEB | ENSP00000262269 | ENSP00000380505 | myosin, heavy chain 14, non-muscle | nebulin | 0.700 |
MYH14 | TNNI1 | ENSP00000262269 | ENSP00000337022 | myosin, heavy chain 14, non-muscle | troponin I type 1 (skeletal, slow) | 0.836 |
MYH14 | TNNI2 | ENSP00000262269 | ENSP00000252898 | myosin, heavy chain 14, non-muscle | troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.811 |
MYH14 | TNNT3 | ENSP00000262269 | ENSP00000278317 | myosin, heavy chain 14, non-muscle | troponin T type 3 (skeletal, fast) | 0.590 |
MYH14 | TPM2 | ENSP00000262269 | ENSP00000354219 | myosin, heavy chain 14, non-muscle | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.771 |
MYH14 | TTN | ENSP00000262269 | ENSP00000343764 | myosin, heavy chain 14, non-muscle | titin | 0.975 |