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STRINGSTRING
MYH14 MYH14 MYH8 MYH8 MYBPC1 MYBPC1 NEB NEB MYH6 MYH6 MYH3 MYH3 TTN TTN TPM2 TPM2 TNNI2 TNNI2 TNNI1 TNNI1 TNNT3 TNNT3
"MYBPC1" - myosin binding protein C, slow type in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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[Homology]
Score
MYBPC1myosin binding protein C, slow type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (1171 aa)    
Predicted Functional Partners:
TTN
titin (33423 aa)
      score_image score_image score_image score_image score_image 0.969
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction (1940 aa)
      score_image   score_image score_image   0.959
TNNT3
troponin T type 3 (skeletal, fast) (258 aa)
      score_image   score_image score_image   0.946
MYH14
myosin, heavy chain 14, non-muscle (2036 aa)
          score_image score_image   0.938
TNNI2
troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (182 aa)
      score_image   score_image score_image   0.938
NEB
nebulin (8525 aa)
      score_image   score_image score_image   0.931
MYH6
myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction (1939 aa)
          score_image score_image   0.929
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction (1937 aa)
      score_image   score_image score_image   0.929
TPM2
tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) (284 aa)
          score_image score_image   0.929
TNNI1
troponin I type 1 (skeletal, slow) (187 aa)
      score_image   score_image score_image   0.928
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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