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HYDIN HYDIN NPM3 NPM3 GFPT1 GFPT1 OGT OGT MGEA5 MGEA5 FKBP5 FKBP5 UBC UBC HEXA HEXA AURKB AURKB HEXB HEXB CYLD CYLD
"MGEA5" - meningioma expressed antigen 5 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
MGEA5meningioma expressed antigen 5 (hyaluronidase); Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates ’Lys-8’ of histone H4 and ’Lys-14’ of histone H3 (916 aa)    
Predicted Functional Partners:
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...] (1046 aa)
        score_image   score_image   0.978
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.921
AURKB
aurora kinase B (344 aa)
            score_image   0.901
HEXA
hexosaminidase A (alpha polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity (529 aa)
            score_image   0.816
CYLD
cylindromatosis (turban tumor syndrome); Protease that specifically cleaves ’Lys-63’-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulatio [...] (956 aa)
        score_image   score_image   0.768
GFPT1
glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (681 aa)
            score_image   0.692
HEXB
hexosaminidase B (beta polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues (556 aa)
            score_image   0.680
NPM3
nucleophosmin/nucleoplasmin 3; May act as a chaperone (178 aa)
            score_image   0.644
FKBP5
FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (457 aa)
        score_image   score_image   0.638
HYDIN
HYDIN, axonemal central pair apparatus protein (1017 aa)
            score_image   0.604
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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