PPEF1 protein (Homo sapiens) - STRING network view

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PPEF1

protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development (653 aa)

Predicted Functional Partners:

RHO

0.963

SAG

0.917

SCML2

0.776

NHS

0.758

CALM2

0.695

PHLPP1

0.673

CALM1

0.670

CALM3

0.670

PHLPP2

0.662

CDKL5

0.659

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM1	CALM2	ENSP00000349467	ENSP00000272298	calmodulin 1 (phosphorylase kinase, delta)	calmodulin 2 (phosphorylase kinase, delta)	0.901
CALM1	CALM3	ENSP00000349467	ENSP00000291295	calmodulin 1 (phosphorylase kinase, delta)	calmodulin 3 (phosphorylase kinase, delta)	0.901
CALM1	PPEF1	ENSP00000349467	ENSP00000354871	calmodulin 1 (phosphorylase kinase, delta)	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	0.670
CALM2	CALM1	ENSP00000272298	ENSP00000349467	calmodulin 2 (phosphorylase kinase, delta)	calmodulin 1 (phosphorylase kinase, delta)	0.901
CALM2	CALM3	ENSP00000272298	ENSP00000291295	calmodulin 2 (phosphorylase kinase, delta)	calmodulin 3 (phosphorylase kinase, delta)	0.901
CALM2	PPEF1	ENSP00000272298	ENSP00000354871	calmodulin 2 (phosphorylase kinase, delta)	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	0.695
CALM3	CALM1	ENSP00000291295	ENSP00000349467	calmodulin 3 (phosphorylase kinase, delta)	calmodulin 1 (phosphorylase kinase, delta)	0.901
CALM3	CALM2	ENSP00000291295	ENSP00000272298	calmodulin 3 (phosphorylase kinase, delta)	calmodulin 2 (phosphorylase kinase, delta)	0.901
CALM3	PPEF1	ENSP00000291295	ENSP00000354871	calmodulin 3 (phosphorylase kinase, delta)	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	0.670
CDKL5	NHS	ENSP00000369325	ENSP00000369400	cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2	Nance-Horan syndrome (congenital cataracts and dental anomalies); May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development	0.860
CDKL5	PPEF1	ENSP00000369325	ENSP00000354871	cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	0.659
CDKL5	SCML2	ENSP00000369325	ENSP00000251900	cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2	sex comb on midleg-like 2 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)	0.606
NHS	CDKL5	ENSP00000369400	ENSP00000369325	Nance-Horan syndrome (congenital cataracts and dental anomalies); May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development	cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2	0.860
NHS	PPEF1	ENSP00000369400	ENSP00000354871	Nance-Horan syndrome (congenital cataracts and dental anomalies); May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	0.758
NHS	SCML2	ENSP00000369400	ENSP00000251900	Nance-Horan syndrome (congenital cataracts and dental anomalies); May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development	sex comb on midleg-like 2 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)	0.750
PHLPP1	PHLPP2	ENSP00000262719	ENSP00000348611	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.999
PHLPP1	PPEF1	ENSP00000262719	ENSP00000354871	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	0.673
PHLPP2	PHLPP1	ENSP00000348611	ENSP00000262719	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.999
PHLPP2	PPEF1	ENSP00000348611	ENSP00000354871	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	0.662
PPEF1	CALM1	ENSP00000354871	ENSP00000349467	protein phosphatase, EF-hand calcium binding domain 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development	calmodulin 1 (phosphorylase kinase, delta)	0.670

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