Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
OG12 OG12 IFT140 IFT140 CLCN7 CLCN7 BAALC BAALC TELO2 TELO2 DNASE1L1 DNASE1L1 GPR144 GPR144 VEPH1 VEPH1 AP4B1 AP4B1 PLEK PLEK PMPCB PMPCB
"VEPH1" - ventricular zone expressed PH domain homolog 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VEPH1ventricular zone expressed PH domain homolog 1 (zebrafish) (833 aa)    
Predicted Functional Partners:
DNASE1L1
deoxyribonuclease I-like 1 (302 aa)
            score_image   0.661
TELO2
TEL2, telomere maintenance 2, homolog (S. cerevisiae); Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complex [...] (837 aa)
            score_image   0.660
IFT140
intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance (1462 aa)
            score_image   0.650
CLCN7
chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (805 aa)
            score_image   0.617
BAALC
brain and acute leukemia, cytoplasmic; May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By similarity) (145 aa)
            score_image   0.523
AP4B1
adaptor-related protein complex 4, beta 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (739 aa)
            score_image   0.523
GPR144
G protein-coupled receptor 144; Orphan receptor (963 aa)
            score_image   0.512
PMPCB
peptidase (mitochondrial processing) beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (489 aa)
            score_image   0.499
OG12
short stature homeobox protein 2 isoform c ; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation (319 aa)
            score_image   0.498
PLEK
pleckstrin; Major protein kinase C substrate of platelets (350 aa)
            score_image   0.489
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (41%)