node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCR | CRKL | ENSP00000303507 | ENSP00000346300 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.998 |
BCR | GAB2 | ENSP00000303507 | ENSP00000354952 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | GRB2-associated binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis | 0.993 |
BCR | GRAP2 | ENSP00000303507 | ENSP00000339186 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.454 |
BCR | GRB2 | ENSP00000303507 | ENSP00000339007 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.999 |
BCR | LYN | ENSP00000303507 | ENSP00000428924 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...] | 0.975 |
BCR | PIK3R1 | ENSP00000303507 | ENSP00000274335 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.959 |
BCR | PTPN11 | ENSP00000303507 | ENSP00000340944 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.802 |
BCR | SHC1 | ENSP00000303507 | ENSP00000401303 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | SHC (Src homology 2 domain containing) transforming protein 1 | 0.990 |
BCR | SYK | ENSP00000303507 | ENSP00000364898 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.974 |
CRKL | BCR | ENSP00000346300 | ENSP00000303507 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | 0.998 |
CRKL | GAB2 | ENSP00000346300 | ENSP00000354952 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | GRB2-associated binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis | 0.989 |
CRKL | GRAP2 | ENSP00000346300 | ENSP00000339186 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.958 |
CRKL | GRB2 | ENSP00000346300 | ENSP00000339007 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.965 |
CRKL | LYN | ENSP00000346300 | ENSP00000428924 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...] | 0.959 |
CRKL | MAPK1 | ENSP00000346300 | ENSP00000215832 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.793 |
CRKL | PIK3R1 | ENSP00000346300 | ENSP00000274335 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.998 |
CRKL | PTPN11 | ENSP00000346300 | ENSP00000340944 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.987 |
CRKL | SHC1 | ENSP00000346300 | ENSP00000401303 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | SHC (Src homology 2 domain containing) transforming protein 1 | 0.894 |
CRKL | SYK | ENSP00000346300 | ENSP00000364898 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.963 |
GAB2 | BCR | ENSP00000354952 | ENSP00000303507 | GRB2-associated binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | 0.993 |