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BCR BCR GRB2 GRB2 SHC1 SHC1 SYK SYK GRAP2 GRAP2 GAB2 GAB2 CRKL CRKL PIK3R1 PIK3R1 LYN LYN MAPK1 MAPK1 PTPN11 PTPN11
"GAB2" - GRB2-associated binding protein 2 in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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GAB2GRB2-associated binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis (676 aa)    
Predicted Functional Partners:
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (217 aa)
        score_image score_image score_image   0.999
PTPN11
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity (593 aa)
        score_image score_image score_image   0.999
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (724 aa)
        score_image score_image score_image   0.999
SHC1
SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)
      score_image score_image score_image score_image   0.999
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...] (512 aa)
        score_image score_image score_image   0.995
BCR
breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (1271 aa)
        score_image score_image score_image   0.993
SYK
spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] (635 aa)
        score_image score_image score_image   0.990
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals (303 aa)
        score_image score_image score_image   0.989
GRAP2
GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc (330 aa)
        score_image   score_image   0.988
MAPK1
mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] (360 aa)
        score_image score_image score_image   0.984
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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