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COL4A3BP COL4A3BP ATIC ATIC ABCG4 ABCG4 ABCG1 ABCG1 NR1H2 NR1H2 RARS RARS ALB ALB SCARB1 SCARB1 NR1H3 NR1H3 NPC1 NPC1 APOA1 APOA1
"ABCG1" - ATP-binding cassette, sub-family G in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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[Homology]
Score
ABCG1ATP-binding cassette, sub-family G (WHITE), member 1 (678 aa)    
Predicted Functional Partners:
APOA1
apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (267 aa)
          score_image score_image   0.975
SCARB1
scavenger receptor class B, member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for h [...] (509 aa)
            score_image   0.963
NR1H3
nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) (447 aa)
            score_image   0.938
NPC1
Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] (1278 aa)
            score_image   0.911
NR1H2
nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) (460 aa)
            score_image   0.910
ALB
albumin (609 aa)
            score_image   0.874
RARS
arginyl-tRNA synthetase; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (660 aa)
            score_image   0.833
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis (592 aa)
            score_image   0.831
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein (752 aa)
            score_image   0.818
ABCG4
ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis (646 aa)
    score_image   score_image   score_image score_image 0.817
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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