node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCG1 | ABCG4 | ENSP00000354995 | ENSP00000304111 | ATP-binding cassette, sub-family G (WHITE), member 1 | ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis | 0.817 |
ABCG1 | ALB | ENSP00000354995 | ENSP00000295897 | ATP-binding cassette, sub-family G (WHITE), member 1 | albumin | 0.874 |
ABCG1 | APOA1 | ENSP00000354995 | ENSP00000236850 | ATP-binding cassette, sub-family G (WHITE), member 1 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.975 |
ABCG1 | ATIC | ENSP00000354995 | ENSP00000236959 | ATP-binding cassette, sub-family G (WHITE), member 1 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.831 |
ABCG1 | COL4A3BP | ENSP00000354995 | ENSP00000369862 | ATP-binding cassette, sub-family G (WHITE), member 1 | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 0.818 |
ABCG1 | NPC1 | ENSP00000354995 | ENSP00000269228 | ATP-binding cassette, sub-family G (WHITE), member 1 | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | 0.911 |
ABCG1 | NR1H2 | ENSP00000354995 | ENSP00000253727 | ATP-binding cassette, sub-family G (WHITE), member 1 | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.910 |
ABCG1 | NR1H3 | ENSP00000354995 | ENSP00000387946 | ATP-binding cassette, sub-family G (WHITE), member 1 | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.938 |
ABCG1 | RARS | ENSP00000354995 | ENSP00000231572 | ATP-binding cassette, sub-family G (WHITE), member 1 | arginyl-tRNA synthetase; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 | 0.833 |
ABCG1 | SCARB1 | ENSP00000354995 | ENSP00000261693 | ATP-binding cassette, sub-family G (WHITE), member 1 | scavenger receptor class B, member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for h [...] | 0.963 |
ABCG4 | ABCG1 | ENSP00000304111 | ENSP00000354995 | ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.817 |
ABCG4 | APOA1 | ENSP00000304111 | ENSP00000236850 | ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.485 |
ABCG4 | NR1H2 | ENSP00000304111 | ENSP00000253727 | ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.592 |
ABCG4 | NR1H3 | ENSP00000304111 | ENSP00000387946 | ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.605 |
ABCG4 | SCARB1 | ENSP00000304111 | ENSP00000261693 | ATP-binding cassette, sub-family G (WHITE), member 4; May be involved in macrophage lipid homeostasis | scavenger receptor class B, member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for h [...] | 0.501 |
ALB | ABCG1 | ENSP00000295897 | ENSP00000354995 | albumin | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.874 |
ALB | APOA1 | ENSP00000295897 | ENSP00000236850 | albumin | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.972 |
ALB | ATIC | ENSP00000295897 | ENSP00000236959 | albumin | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.499 |
ALB | RARS | ENSP00000295897 | ENSP00000231572 | albumin | arginyl-tRNA synthetase; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 | 0.416 |
ALB | SCARB1 | ENSP00000295897 | ENSP00000261693 | albumin | scavenger receptor class B, member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for h [...] | 0.538 |