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SLIT2 SLIT2 POU3F1 POU3F1 SLIT3 SLIT3 SLIT1 SLIT1 BMP2 BMP2 BMP4 BMP4 POU3F3 POU3F3 ASCL1 ASCL1 DLL1 DLL1 MYT1L MYT1L SOX11 SOX11
"POU3F3" - POU class 3 homeobox 3 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
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co-expression
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protein homology
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[Homology]
Score
POU3F3POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) (500 aa)    
Predicted Functional Partners:
SLIT3
slit homolog 3 (Drosophila); May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors (1523 aa)
            score_image   0.770
SLIT1
slit homolog 1 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (1534 aa)
            score_image   0.770
SOX11
SRY (sex determining region Y)-box 11; Probably important in the developing nervous system. May also have a role in tissue modeling during development (441 aa)
        score_image   score_image   0.766
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
            score_image   0.766
SLIT2
slit homolog 2 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once [...] (1529 aa)
            score_image   0.763
MYT1L
myelin transcription factor 1-like; May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS (By similarity) (1184 aa)
            score_image   0.760
POU3F1
POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis (451 aa)
            score_image   0.749
ASCL1
achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) (236 aa)
            score_image   0.748
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
            score_image   0.740
DLL1
delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (723 aa)
            score_image   0.680
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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