| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C16orf59 | FEZ1 | ENSP00000355022 | ENSP00000278919 | chromosome 16 open reading frame 59 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.443 |
| C16orf59 | FEZ2 | ENSP00000355022 | ENSP00000368547 | chromosome 16 open reading frame 59 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | 0.654 |
| C16orf59 | MEIOB | ENSP00000355022 | ENSP00000314484 | chromosome 16 open reading frame 59 | meiosis specific with OB domains; May be involved in early meiosis (By similarity) | 0.588 |
| C16orf59 | PDCD7 | ENSP00000355022 | ENSP00000204549 | chromosome 16 open reading frame 59 | programmed cell death 7; Promotes apoptosis when overexpressed (By similarity) | 0.499 |
| C16orf59 | RAB3GAP1 | ENSP00000355022 | ENSP00000411418 | chromosome 16 open reading frame 59 | RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | 0.472 |
| C16orf59 | SAP30L | ENSP00000355022 | ENSP00000297109 | chromosome 16 open reading frame 59 | SAP30-like; Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus | 0.509 |
| C16orf59 | SCOC | ENSP00000355022 | ENSP00000377751 | chromosome 16 open reading frame 59 | short coiled-coil protein | 0.473 |
| C16orf59 | WWC1 | ENSP00000355022 | ENSP00000427772 | chromosome 16 open reading frame 59 | WW and C2 domain containing 1; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates dir [...] | 0.457 |
| C16orf59 | ZNF251 | ENSP00000355022 | ENSP00000292562 | chromosome 16 open reading frame 59 | zinc finger protein 251; May be involved in transcriptional regulation | 0.636 |
| FEZ1 | C16orf59 | ENSP00000278919 | ENSP00000355022 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | chromosome 16 open reading frame 59 | 0.443 |
| FEZ1 | FEZ2 | ENSP00000278919 | ENSP00000368547 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | 0.486 |
| FEZ1 | PDCD7 | ENSP00000278919 | ENSP00000204549 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | programmed cell death 7; Promotes apoptosis when overexpressed (By similarity) | 0.470 |
| FEZ1 | RAB3GAP1 | ENSP00000278919 | ENSP00000411418 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | 0.460 |
| FEZ1 | SAP30L | ENSP00000278919 | ENSP00000297109 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | SAP30-like; Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus | 0.599 |
| FEZ1 | SCOC | ENSP00000278919 | ENSP00000377751 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | short coiled-coil protein | 0.988 |
| FEZ1 | WWC1 | ENSP00000278919 | ENSP00000427772 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | WW and C2 domain containing 1; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates dir [...] | 0.443 |
| FEZ1 | ZNF251 | ENSP00000278919 | ENSP00000292562 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | zinc finger protein 251; May be involved in transcriptional regulation | 0.443 |
| FEZ2 | C16orf59 | ENSP00000368547 | ENSP00000355022 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | chromosome 16 open reading frame 59 | 0.654 |
| FEZ2 | FEZ1 | ENSP00000368547 | ENSP00000278919 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.486 |
| FEZ2 | PDCD7 | ENSP00000368547 | ENSP00000204549 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | programmed cell death 7; Promotes apoptosis when overexpressed (By similarity) | 0.491 |
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