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STRINGSTRING
PANX3 PANX3 BRK1 BRK1 LCK LCK PCDH18 PCDH18 KCNJ13 KCNJ13 C3orf58 C3orf58 DAB1 DAB1
"PCDH18" - protocadherin 18 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCDH18protocadherin 18; Potential calcium-dependent cell-adhesion protein (1135 aa)    
Predicted Functional Partners:
LCK
lymphocyte-specific protein tyrosine kinase (509 aa)
            score_image   0.800
C3orf58
chromosome 3 open reading frame 58 (430 aa)
            score_image   0.756
DAB1
disabled homolog 1 (Drosophila) (555 aa)
        score_image       0.576
KCNJ13
potassium inwardly-rectifying channel, subfamily J, member 13; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and [...] (360 aa)
            score_image   0.500
BRK1
BRICK1, SCAR/WAVE actin-nucleating complex subunit; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (75 aa)
        score_image       0.487
PANX3
pannexin 3; Structural component of the gap junctions and the hemichannels (392 aa)
            score_image   0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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