FCRL2 protein (Homo sapiens) - STRING network view

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FCRL2

Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development (508 aa)

Predicted Functional Partners:

PIGR

0.750

FCGR2A

0.627

FCGR2B

0.583

MUC1

0.511

SULT2B1

0.489

NCK2

0.485

BCL9

0.483

CD3E

0.476

CD3G

0.463

HRAS

0.438

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL9	FCRL2	ENSP00000234739	ENSP00000355157	B-cell CLL/lymphoma 9	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	0.483
BCL9	HRAS	ENSP00000234739	ENSP00000309845	B-cell CLL/lymphoma 9	v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity	0.461
CD3E	CD3G	ENSP00000354566	ENSP00000431445	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.998
CD3E	FCRL2	ENSP00000354566	ENSP00000355157	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	0.476
CD3E	NCK2	ENSP00000354566	ENSP00000233154	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	NCK adaptor protein 2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling	0.818
CD3G	CD3E	ENSP00000431445	ENSP00000354566	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.998
CD3G	FCGR2A	ENSP00000431445	ENSP00000271450	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens	0.900
CD3G	FCRL2	ENSP00000431445	ENSP00000355157	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	0.463
FCGR2A	CD3G	ENSP00000271450	ENSP00000431445	Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.900
FCGR2A	FCRL2	ENSP00000271450	ENSP00000355157	Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	0.627
FCGR2A	HRAS	ENSP00000271450	ENSP00000309845	Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens	v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity	0.404
FCGR2A	PIGR	ENSP00000271450	ENSP00000348888	Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens	polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment	0.609
FCGR2A	SULT2B1	ENSP00000271450	ENSP00000201586	Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens	sulfotransferase family, cytosolic, 2B, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol	0.560
FCGR2B	FCRL2	ENSP00000351497	ENSP00000355157	Fc fragment of IgG, low affinity IIb, receptor (CD32); Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	0.583
FCRL2	BCL9	ENSP00000355157	ENSP00000234739	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	B-cell CLL/lymphoma 9	0.483
FCRL2	CD3E	ENSP00000355157	ENSP00000354566	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.476
FCRL2	CD3G	ENSP00000355157	ENSP00000431445	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.463
FCRL2	FCGR2A	ENSP00000355157	ENSP00000271450	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens	0.627
FCRL2	FCGR2B	ENSP00000355157	ENSP00000351497	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	Fc fragment of IgG, low affinity IIb, receptor (CD32); Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis	0.583
FCRL2	HRAS	ENSP00000355157	ENSP00000309845	Fc receptor-like 2; May have an regulatory role in normal and neoplastic B cell development	v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity	0.438

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