node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG2A | ATG2B | ENSP00000366475 | ENSP00000353010 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2A | ATG9A | ENSP00000366475 | ENSP00000355173 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 9A | 0.976 |
ATG2A | BECN1 | ENSP00000366475 | ENSP00000355231 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.634 |
ATG2A | MAP1LC3A | ENSP00000366475 | ENSP00000363970 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.556 |
ATG2A | ULK1 | ENSP00000366475 | ENSP00000324560 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] | 0.807 |
ATG2A | ULK2 | ENSP00000366475 | ENSP00000354877 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 2 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. [...] | 0.794 |
ATG2A | ULK3 | ENSP00000366475 | ENSP00000400312 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 3 (C. elegans); Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand- interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH- dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well [...] | 0.748 |
ATG2A | WIPI1 | ENSP00000366475 | ENSP00000262139 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.997 |
ATG2A | WIPI2 | ENSP00000366475 | ENSP00000288828 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.988 |
ATG2B | ATG2A | ENSP00000353010 | ENSP00000366475 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2B | ATG9A | ENSP00000353010 | ENSP00000355173 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 9A | 0.969 |
ATG2B | BECN1 | ENSP00000353010 | ENSP00000355231 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.680 |
ATG2B | MAP1LC3A | ENSP00000353010 | ENSP00000363970 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.565 |
ATG2B | ULK1 | ENSP00000353010 | ENSP00000324560 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] | 0.824 |
ATG2B | ULK2 | ENSP00000353010 | ENSP00000354877 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 2 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. [...] | 0.806 |
ATG2B | ULK3 | ENSP00000353010 | ENSP00000400312 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 3 (C. elegans); Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand- interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH- dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well [...] | 0.748 |
ATG2B | WIPI1 | ENSP00000353010 | ENSP00000262139 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.986 |
ATG2B | WIPI2 | ENSP00000353010 | ENSP00000288828 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.985 |
ATG9A | ATG2A | ENSP00000355173 | ENSP00000366475 | autophagy related 9A | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.976 |
ATG9A | ATG2B | ENSP00000355173 | ENSP00000353010 | autophagy related 9A | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.969 |