RUSC2 protein (Homo sapiens) - STRING network view

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Score

RUSC2

RUN and SH3 domain containing 2 (1516 aa)

Predicted Functional Partners:

RAB1A

0.969

RAB1B

0.936

GOLGA2

0.860

CHMP3

0.618

CSNK1G1

0.575

TDO2

0.572

MAGEC1

0.572

CSNK1G3

0.564

CSNK1G2

0.564

GIT1

0.504

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP3	RUSC2	ENSP00000405575	ENSP00000355177	charged multivesicular body protein 3	RUN and SH3 domain containing 2	0.618
CHMP3	TDO2	ENSP00000405575	ENSP00000444788	charged multivesicular body protein 3	tryptophan 2,3-dioxygenase; Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)	0.617
CSNK1G1	RUSC2	ENSP00000305777	ENSP00000355177	casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN	RUN and SH3 domain containing 2	0.575
CSNK1G1	TDO2	ENSP00000305777	ENSP00000444788	casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN	tryptophan 2,3-dioxygenase; Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)	0.404
CSNK1G2	RUSC2	ENSP00000255641	ENSP00000355177	casein kinase 1, gamma 2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteas [...]	RUN and SH3 domain containing 2	0.564
CSNK1G2	TDO2	ENSP00000255641	ENSP00000444788	casein kinase 1, gamma 2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteas [...]	tryptophan 2,3-dioxygenase; Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)	0.404
CSNK1G3	RUSC2	ENSP00000353904	ENSP00000355177	casein kinase 1, gamma 3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity)	RUN and SH3 domain containing 2	0.564
CSNK1G3	TDO2	ENSP00000353904	ENSP00000444788	casein kinase 1, gamma 3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity)	tryptophan 2,3-dioxygenase; Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)	0.404
GIT1	RUSC2	ENSP00000378338	ENSP00000355177	G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes	RUN and SH3 domain containing 2	0.504
GOLGA2	RAB1A	ENSP00000416097	ENSP00000387286	golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	0.999
GOLGA2	RAB1B	ENSP00000416097	ENSP00000310226	golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments	0.937
GOLGA2	RUSC2	ENSP00000416097	ENSP00000355177	golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure	RUN and SH3 domain containing 2	0.860
MAGEC1	RUSC2	ENSP00000285879	ENSP00000355177	melanoma antigen family C, 1	RUN and SH3 domain containing 2	0.572
RAB1A	GOLGA2	ENSP00000387286	ENSP00000416097	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure	0.999
RAB1A	RUSC2	ENSP00000387286	ENSP00000355177	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	RUN and SH3 domain containing 2	0.969
RAB1B	GOLGA2	ENSP00000310226	ENSP00000416097	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments	golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure	0.937
RAB1B	RUSC2	ENSP00000310226	ENSP00000355177	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments	RUN and SH3 domain containing 2	0.936
RUSC2	CHMP3	ENSP00000355177	ENSP00000405575	RUN and SH3 domain containing 2	charged multivesicular body protein 3	0.618
RUSC2	CSNK1G1	ENSP00000355177	ENSP00000305777	RUN and SH3 domain containing 2	casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN	0.575
RUSC2	CSNK1G2	ENSP00000355177	ENSP00000255641	RUN and SH3 domain containing 2	casein kinase 1, gamma 2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteas [...]	0.564

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