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LTV1 LTV1 TSR1 TSR1 BYSL BYSL PNO1 PNO1 POLRMT POLRMT TFB2M TFB2M UTP15 UTP15 GABPA GABPA TFAM TFAM NRF1 NRF1 PPARGC1A PPARGC1A
"TFB2M" - transcription factor B2, mitochondrial in Homo sapiens
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Predicted Interactions
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TFB2Mtranscription factor B2, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity (396 aa)    
Predicted Functional Partners:
POLRMT
polymerase (RNA) mitochondrial (DNA directed); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) (1230 aa)
        score_image score_image score_image   0.999
TFAM
transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and c [...] (246 aa)
        score_image score_image score_image   0.999
BYSL
bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa)
      score_image score_image   score_image   0.983
NRF1
nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (503 aa)
          score_image score_image   0.968
PNO1
partner of NOB1 homolog (S. cerevisiae) (252 aa)
      score_image score_image   score_image   0.965
TSR1
TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) (804 aa)
      score_image score_image   score_image   0.958
GABPA
GA binding protein transcription factor, alpha subunit 60kDa; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene (454 aa)
          score_image score_image   0.947
LTV1
LTV1 homolog (S. cerevisiae) (475 aa)
      score_image score_image   score_image   0.947
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (798 aa)
          score_image score_image   0.944
UTP15
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (518 aa)
      score_image score_image       0.943
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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