node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFCAB2 | GALNT2 | ENSP00000355480 | ENSP00000355632 | EF-hand calcium binding domain 2 | UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region | 0.623 |
EFCAB2 | MYO1G | ENSP00000355480 | ENSP00000258787 | EF-hand calcium binding domain 2 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | 0.658 |
EFCAB2 | MYO5A | ENSP00000355480 | ENSP00000382177 | EF-hand calcium binding domain 2 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.700 |
EFCAB2 | MYO5B | ENSP00000355480 | ENSP00000285039 | EF-hand calcium binding domain 2 | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) | 0.700 |
EFCAB2 | MYO5C | ENSP00000355480 | ENSP00000261839 | EF-hand calcium binding domain 2 | myosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues | 0.700 |
EFCAB2 | OBSCN | ENSP00000355480 | ENSP00000455507 | EF-hand calcium binding domain 2 | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.679 |
EFCAB2 | POTEE | ENSP00000355480 | ENSP00000439189 | EF-hand calcium binding domain 2 | POTE ankyrin domain family member E | 0.628 |
EFCAB2 | POTEF | ENSP00000355480 | ENSP00000350052 | EF-hand calcium binding domain 2 | POTE ankyrin domain family, member F | 0.628 |
EFCAB2 | POTEI | ENSP00000355480 | ENSP00000392718 | EF-hand calcium binding domain 2 | POTE ankyrin domain family, member I | 0.628 |
EFCAB2 | POTEJ | ENSP00000355480 | ENSP00000387176 | EF-hand calcium binding domain 2 | POTE ankyrin domain family, member J | 0.628 |
GALNT2 | EFCAB2 | ENSP00000355632 | ENSP00000355480 | UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region | EF-hand calcium binding domain 2 | 0.623 |
MYO1G | EFCAB2 | ENSP00000258787 | ENSP00000355480 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | EF-hand calcium binding domain 2 | 0.658 |
MYO1G | OBSCN | ENSP00000258787 | ENSP00000455507 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.562 |
MYO1G | POTEE | ENSP00000258787 | ENSP00000439189 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | POTE ankyrin domain family member E | 0.724 |
MYO1G | POTEF | ENSP00000258787 | ENSP00000350052 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | POTE ankyrin domain family, member F | 0.724 |
MYO1G | POTEI | ENSP00000258787 | ENSP00000392718 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | POTE ankyrin domain family, member I | 0.724 |
MYO1G | POTEJ | ENSP00000258787 | ENSP00000387176 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | POTE ankyrin domain family, member J | 0.724 |
MYO5A | EFCAB2 | ENSP00000382177 | ENSP00000355480 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | EF-hand calcium binding domain 2 | 0.700 |
MYO5A | OBSCN | ENSP00000382177 | ENSP00000455507 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.631 |
MYO5A | POTEE | ENSP00000382177 | ENSP00000439189 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | POTE ankyrin domain family member E | 0.750 |