CEP170 protein (Homo sapiens) - STRING network view

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CEP170

centrosomal protein 170kDa; Plays a role in microtubule organization (1584 aa)

Predicted Functional Partners:

KIAA1967

0.988

SERPINB6

0.971

SNAPIN

0.971

BEGAIN

0.971

PLK1

0.929

CENPO

0.765

NEDD1

0.686

KBTBD2

0.627

UBC

0.621

NEK2

0.607

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BEGAIN	CEP170	ENSP00000347301	ENSP00000355500	brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD)	centrosomal protein 170kDa; Plays a role in microtubule organization	0.971
CENPO	CEP170	ENSP00000260662	ENSP00000355500	centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex	centrosomal protein 170kDa; Plays a role in microtubule organization	0.765
CENPO	PLK1	ENSP00000260662	ENSP00000300093	centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex	polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]	0.908
CEP170	BEGAIN	ENSP00000355500	ENSP00000347301	centrosomal protein 170kDa; Plays a role in microtubule organization	brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD)	0.971
CEP170	CENPO	ENSP00000355500	ENSP00000260662	centrosomal protein 170kDa; Plays a role in microtubule organization	centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex	0.765
CEP170	KBTBD2	ENSP00000355500	ENSP00000302586	centrosomal protein 170kDa; Plays a role in microtubule organization	kelch repeat and BTB (POZ) domain containing 2	0.627
CEP170	KIAA1967	ENSP00000355500	ENSP00000310670	centrosomal protein 170kDa; Plays a role in microtubule organization	KIAA1967	0.988
CEP170	NEDD1	ENSP00000355500	ENSP00000451211	centrosomal protein 170kDa; Plays a role in microtubule organization	neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle	0.686
CEP170	NEK2	ENSP00000355500	ENSP00000355966	centrosomal protein 170kDa; Plays a role in microtubule organization	NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...]	0.607
CEP170	PLK1	ENSP00000355500	ENSP00000300093	centrosomal protein 170kDa; Plays a role in microtubule organization	polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]	0.929
CEP170	SERPINB6	ENSP00000355500	ENSP00000338358	centrosomal protein 170kDa; Plays a role in microtubule organization	serpin peptidase inhibitor, clade B (ovalbumin), member 6; May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss	0.971
CEP170	SNAPIN	ENSP00000355500	ENSP00000357674	centrosomal protein 170kDa; Plays a role in microtubule organization	SNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion [...]	0.971
CEP170	UBC	ENSP00000355500	ENSP00000344818	centrosomal protein 170kDa; Plays a role in microtubule organization	ubiquitin C	0.621
KBTBD2	CEP170	ENSP00000302586	ENSP00000355500	kelch repeat and BTB (POZ) domain containing 2	centrosomal protein 170kDa; Plays a role in microtubule organization	0.627
KBTBD2	UBC	ENSP00000302586	ENSP00000344818	kelch repeat and BTB (POZ) domain containing 2	ubiquitin C	0.729
KIAA1967	CEP170	ENSP00000310670	ENSP00000355500	KIAA1967	centrosomal protein 170kDa; Plays a role in microtubule organization	0.988
KIAA1967	UBC	ENSP00000310670	ENSP00000344818	KIAA1967	ubiquitin C	0.942
NEDD1	CEP170	ENSP00000451211	ENSP00000355500	neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle	centrosomal protein 170kDa; Plays a role in microtubule organization	0.686
NEDD1	NEK2	ENSP00000451211	ENSP00000355966	neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle	NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...]	0.927
NEDD1	PLK1	ENSP00000451211	ENSP00000300093	neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle	polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]	0.989

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