node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ILKAP | KIAA1804 | ENSP00000254654 | ENSP00000355583 | integrin-linked kinase-associated serine/threonine phosphatase; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | 0.660 |
ILKAP | LRGUK | ENSP00000254654 | ENSP00000285928 | integrin-linked kinase-associated serine/threonine phosphatase; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation | leucine-rich repeats and guanylate kinase domain containing | 0.621 |
KIAA1804 | ILKAP | ENSP00000355583 | ENSP00000254654 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | integrin-linked kinase-associated serine/threonine phosphatase; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation | 0.660 |
KIAA1804 | LRGUK | ENSP00000355583 | ENSP00000285928 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | leucine-rich repeats and guanylate kinase domain containing | 0.688 |
KIAA1804 | PHLPP1 | ENSP00000355583 | ENSP00000262719 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] | 0.788 |
KIAA1804 | PHLPP2 | ENSP00000355583 | ENSP00000348611 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | 0.788 |
KIAA1804 | PP2D1 | ENSP00000355583 | ENSP00000373702 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | protein phosphatase 2C-like domain containing 1 | 0.660 |
KIAA1804 | PPM1D | ENSP00000355583 | ENSP00000306682 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins | 0.660 |
KIAA1804 | PPM1E | ENSP00000355583 | ENSP00000312411 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 | 0.660 |
KIAA1804 | PPM1F | ENSP00000355583 | ENSP00000263212 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | protein phosphatase, Mg2+/Mn2+ dependent, 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis | 0.660 |
KIAA1804 | PPM1K | ENSP00000355583 | ENSP00000295908 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | protein phosphatase, Mg2+/Mn2+ dependent, 1K | 0.660 |
KIAA1804 | PPM1L | ENSP00000355583 | ENSP00000417659 | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6 | 0.660 |
LRGUK | ILKAP | ENSP00000285928 | ENSP00000254654 | leucine-rich repeats and guanylate kinase domain containing | integrin-linked kinase-associated serine/threonine phosphatase; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation | 0.621 |
LRGUK | KIAA1804 | ENSP00000285928 | ENSP00000355583 | leucine-rich repeats and guanylate kinase domain containing | Mitogen-activated protein kinase kinase kinase MLK4 ; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways | 0.688 |
LRGUK | PHLPP1 | ENSP00000285928 | ENSP00000262719 | leucine-rich repeats and guanylate kinase domain containing | PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] | 0.665 |
LRGUK | PHLPP2 | ENSP00000285928 | ENSP00000348611 | leucine-rich repeats and guanylate kinase domain containing | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | 0.665 |
LRGUK | PP2D1 | ENSP00000285928 | ENSP00000373702 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase 2C-like domain containing 1 | 0.621 |
LRGUK | PPM1D | ENSP00000285928 | ENSP00000306682 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins | 0.621 |
LRGUK | PPM1E | ENSP00000285928 | ENSP00000312411 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 | 0.621 |
LRGUK | PPM1F | ENSP00000285928 | ENSP00000263212 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase, Mg2+/Mn2+ dependent, 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis | 0.621 |