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STRINGSTRING
PCNT PCNT TNIK TNIK CCDC141 CCDC141 ATF4 ATF4 DISC1 DISC1 FEZ1 FEZ1 MAP1A MAP1A NDEL1 NDEL1 NRG1 NRG1 PDE4B PDE4B CCDC88A CCDC88A
"DISC1" - disrupted in schizophrenia 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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[Homology]
Score
DISC1disrupted in schizophrenia 1 (755 aa)    
Predicted Functional Partners:
NDEL1
nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] (345 aa)
        score_image   score_image   0.998
PCNT
pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome (3336 aa)
        score_image   score_image   0.967
FEZ1
fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules (392 aa)
        score_image   score_image   0.959
PDE4B
phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents (736 aa)
        score_image   score_image   0.954
ATF4
activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] (351 aa)
        score_image   score_image   0.941
NRG1
neuregulin 1 (645 aa)
            score_image   0.941
CCDC88A
coiled-coil domain containing 88A (1870 aa)
        score_image   score_image   0.934
CCDC141
coiled-coil domain containing 141 (1530 aa)
        score_image   score_image   0.921
TNIK
TRAF2 and NCK interacting kinase (1360 aa)
        score_image   score_image   0.906
MAP1A
microtubule-associated protein 1A; Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements (2803 aa)
        score_image   score_image   0.899
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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