node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF4 | DISC1 | ENSP00000336790 | ENSP00000355593 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | disrupted in schizophrenia 1 | 0.941 |
ATF4 | NDEL1 | ENSP00000336790 | ENSP00000333982 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | 0.439 |
CCDC141 | DISC1 | ENSP00000395995 | ENSP00000355593 | coiled-coil domain containing 141 | disrupted in schizophrenia 1 | 0.921 |
CCDC88A | DISC1 | ENSP00000338728 | ENSP00000355593 | coiled-coil domain containing 88A | disrupted in schizophrenia 1 | 0.934 |
CCDC88A | NDEL1 | ENSP00000338728 | ENSP00000333982 | coiled-coil domain containing 88A | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | 0.500 |
DISC1 | ATF4 | ENSP00000355593 | ENSP00000336790 | disrupted in schizophrenia 1 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | 0.941 |
DISC1 | CCDC141 | ENSP00000355593 | ENSP00000395995 | disrupted in schizophrenia 1 | coiled-coil domain containing 141 | 0.921 |
DISC1 | CCDC88A | ENSP00000355593 | ENSP00000338728 | disrupted in schizophrenia 1 | coiled-coil domain containing 88A | 0.934 |
DISC1 | FEZ1 | ENSP00000355593 | ENSP00000278919 | disrupted in schizophrenia 1 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.959 |
DISC1 | MAP1A | ENSP00000355593 | ENSP00000300231 | disrupted in schizophrenia 1 | microtubule-associated protein 1A; Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements | 0.899 |
DISC1 | NDEL1 | ENSP00000355593 | ENSP00000333982 | disrupted in schizophrenia 1 | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | 0.998 |
DISC1 | NRG1 | ENSP00000355593 | ENSP00000349275 | disrupted in schizophrenia 1 | neuregulin 1 | 0.941 |
DISC1 | PCNT | ENSP00000355593 | ENSP00000352572 | disrupted in schizophrenia 1 | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.967 |
DISC1 | PDE4B | ENSP00000355593 | ENSP00000332116 | disrupted in schizophrenia 1 | phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents | 0.954 |
DISC1 | TNIK | ENSP00000355593 | ENSP00000399511 | disrupted in schizophrenia 1 | TRAF2 and NCK interacting kinase | 0.906 |
FEZ1 | DISC1 | ENSP00000278919 | ENSP00000355593 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | disrupted in schizophrenia 1 | 0.959 |
MAP1A | DISC1 | ENSP00000300231 | ENSP00000355593 | microtubule-associated protein 1A; Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements | disrupted in schizophrenia 1 | 0.899 |
NDEL1 | ATF4 | ENSP00000333982 | ENSP00000336790 | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | 0.439 |
NDEL1 | CCDC88A | ENSP00000333982 | ENSP00000338728 | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | coiled-coil domain containing 88A | 0.500 |
NDEL1 | DISC1 | ENSP00000333982 | ENSP00000355593 | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | disrupted in schizophrenia 1 | 0.998 |