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STRINGSTRING
PTGER3 PTGER3 TSN TSN EIF2C2 EIF2C2 TSNAXIP1 TSNAXIP1 TSNAX TSNAX SUN1 SUN1 UBC UBC AKAP9 AKAP9 GOLGA3 GOLGA3 NSMCE2 NSMCE2 C1D C1D
"TSNAX" - translin-associated factor X in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
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protein homology
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TSNAXtranslin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (290 aa)    
Predicted Functional Partners:
TSN
translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots (228 aa)
      score_image score_image   score_image score_image 0.999
C1D
C1D nuclear receptor corepressor; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3’-5’ end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity) (141 aa)
      score_image score_image   score_image   0.946
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.943
TSNAXIP1
translin-associated factor X interacting protein 1; Possible role in spermatogenesis (By similarity) (658 aa)
        score_image   score_image   0.936
GOLGA3
golgin A3; Golgi auto-antigen; probably involved in maintaining Golgi structure (1498 aa)
        score_image   score_image   0.857
SUN1
Sad1 and UNC84 domain containing 1 (785 aa)
        score_image   score_image   0.821
AKAP9
A kinase (PRKA) anchor protein (yotiao) 9 (3907 aa)
        score_image   score_image   0.778
NSMCE2
non-SMC element 2, MMS21 homolog (S. cerevisiae); E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to [...] (247 aa)
        score_image   score_image   0.776
EIF2C2
eukaryotic translation initiation factor 2C, 2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The ’minimal RISC’ appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC- mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due [...] (859 aa)
        score_image   score_image   0.757
PTGER3
prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] (418 aa)
            score_image   0.744
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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