node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP9 | TSNAX | ENSP00000348573 | ENSP00000355599 | A kinase (PRKA) anchor protein (yotiao) 9 | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.778 |
AKAP9 | TSNAXIP1 | ENSP00000348573 | ENSP00000373485 | A kinase (PRKA) anchor protein (yotiao) 9 | translin-associated factor X interacting protein 1; Possible role in spermatogenesis (By similarity) | 0.424 |
AKAP9 | UBC | ENSP00000348573 | ENSP00000344818 | A kinase (PRKA) anchor protein (yotiao) 9 | ubiquitin C | 0.620 |
C1D | TSNAX | ENSP00000348107 | ENSP00000355599 | C1D nuclear receptor corepressor; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3’-5’ end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity) | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.946 |
C1D | UBC | ENSP00000348107 | ENSP00000344818 | C1D nuclear receptor corepressor; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3’-5’ end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity) | ubiquitin C | 0.483 |
EIF2C2 | TSN | ENSP00000220592 | ENSP00000374332 | eukaryotic translation initiation factor 2C, 2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The ’minimal RISC’ appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC- mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due [...] | translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots | 0.813 |
EIF2C2 | TSNAX | ENSP00000220592 | ENSP00000355599 | eukaryotic translation initiation factor 2C, 2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The ’minimal RISC’ appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC- mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due [...] | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.757 |
EIF2C2 | UBC | ENSP00000220592 | ENSP00000344818 | eukaryotic translation initiation factor 2C, 2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The ’minimal RISC’ appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC- mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due [...] | ubiquitin C | 0.964 |
GOLGA3 | TSNAX | ENSP00000204726 | ENSP00000355599 | golgin A3; Golgi auto-antigen; probably involved in maintaining Golgi structure | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.857 |
GOLGA3 | UBC | ENSP00000204726 | ENSP00000344818 | golgin A3; Golgi auto-antigen; probably involved in maintaining Golgi structure | ubiquitin C | 0.484 |
NSMCE2 | TSNAX | ENSP00000287437 | ENSP00000355599 | non-SMC element 2, MMS21 homolog (S. cerevisiae); E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to [...] | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.776 |
NSMCE2 | UBC | ENSP00000287437 | ENSP00000344818 | non-SMC element 2, MMS21 homolog (S. cerevisiae); E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to [...] | ubiquitin C | 0.721 |
PTGER3 | TSNAX | ENSP00000349003 | ENSP00000355599 | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.744 |
SUN1 | TSNAX | ENSP00000384015 | ENSP00000355599 | Sad1 and UNC84 domain containing 1 | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.821 |
SUN1 | UBC | ENSP00000384015 | ENSP00000344818 | Sad1 and UNC84 domain containing 1 | ubiquitin C | 0.878 |
TSN | EIF2C2 | ENSP00000374332 | ENSP00000220592 | translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots | eukaryotic translation initiation factor 2C, 2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The ’minimal RISC’ appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC- mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due [...] | 0.813 |
TSN | TSNAX | ENSP00000374332 | ENSP00000355599 | translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.999 |
TSN | UBC | ENSP00000374332 | ENSP00000344818 | translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots | ubiquitin C | 0.917 |
TSNAX | AKAP9 | ENSP00000355599 | ENSP00000348573 | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | A kinase (PRKA) anchor protein (yotiao) 9 | 0.778 |
TSNAX | C1D | ENSP00000355599 | ENSP00000348107 | translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | C1D nuclear receptor corepressor; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3’-5’ end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity) | 0.946 |