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STRINGSTRING
CATSPER3 CATSPER3 GTF3C6 GTF3C6 MFSD1 MFSD1 SLC38A9 SLC38A9 C10orf32 C10orf32 FUOM FUOM C1orf131 C1orf131 POLR3H POLR3H ADTRP ADTRP KRT23 KRT23
"C1orf131" - chromosome 1 open reading frame 131 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
C1orf131chromosome 1 open reading frame 131 (293 aa)    
Predicted Functional Partners:
C10orf32
chromosome 10 open reading frame 32 (106 aa)
            score_image   0.567
GTF3C6
general transcription factor IIIC, polypeptide 6, alpha 35kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (213 aa)
            score_image   0.531
SLC38A9
solute carrier family 38, member 9; Putative sodium-dependent amino acid/proton antiporter (By similarity) (561 aa)
            score_image   0.502
CATSPER3
cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] (398 aa)
            score_image   0.499
MFSD1
major facilitator superfamily domain containing 1 (514 aa)
            score_image   0.472
FUOM
fucose mutarotase; Involved in the interconversion between alpha- and beta- L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O- glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes (154 aa)
            score_image   0.472
ADTRP
androgen-dependent TFPI-regulating protein; Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (248 aa)
            score_image   0.454
POLR3H
polymerase (RNA) III (DNA directed) polypeptide H (22.9kD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcrip [...] (204 aa)
            score_image   0.412
KRT23
keratin 23 (histone deacetylase inducible) (422 aa)
            score_image   0.407
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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