node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD2AP | RAB4A | ENSP00000352264 | ENSP00000355651 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.939 |
GDI2 | RAB4A | ENSP00000369538 | ENSP00000355651 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.979 |
GDI2 | RABEP1 | ENSP00000369538 | ENSP00000262477 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | 0.423 |
GRIPAP1 | RAB4A | ENSP00000365624 | ENSP00000355651 | GRIP1 associated protein 1 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.928 |
KIF3A | KIF3B | ENSP00000368020 | ENSP00000364864 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) | 0.981 |
KIF3A | RAB4A | ENSP00000368020 | ENSP00000355651 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.984 |
KIF3B | KIF3A | ENSP00000364864 | ENSP00000368020 | kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | 0.981 |
KIF3B | RAB4A | ENSP00000364864 | ENSP00000355651 | kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.969 |
RAB4A | CD2AP | ENSP00000355651 | ENSP00000352264 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | 0.939 |
RAB4A | GDI2 | ENSP00000355651 | ENSP00000369538 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.979 |
RAB4A | GRIPAP1 | ENSP00000355651 | ENSP00000365624 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | GRIP1 associated protein 1 | 0.928 |
RAB4A | KIF3A | ENSP00000355651 | ENSP00000368020 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | 0.984 |
RAB4A | KIF3B | ENSP00000355651 | ENSP00000364864 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | kinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) | 0.969 |
RAB4A | RABEP1 | ENSP00000355651 | ENSP00000262477 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | 0.995 |
RAB4A | RUFY1 | ENSP00000355651 | ENSP00000325594 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.966 |
RAB4A | STX4 | ENSP00000355651 | ENSP00000317714 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.986 |
RAB4A | TFRC | ENSP00000355651 | ENSP00000353224 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | transferrin receptor (p90, CD71); Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin f [...] | 0.941 |
RAB4A | ZFYVE20 | ENSP00000355651 | ENSP00000253699 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | zinc finger, FYVE domain containing 20; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) | 0.992 |
RABEP1 | GDI2 | ENSP00000262477 | ENSP00000369538 | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.423 |
RABEP1 | RAB4A | ENSP00000262477 | ENSP00000355651 | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.995 |