IBA57 protein (Homo sapiens) - STRING network view

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IBA57

IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity) (356 aa)

Predicted Functional Partners:

ISCA2

0.987

ISCA1

0.986

LYRM4

0.852

LIPT2

0.781

GLRX5

0.774

HSCB

0.754

ISCU

0.750

NUBPL

0.744

BOLA3

0.728

NFS1

0.687

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOLA3	GLRX5	ENSP00000331369	ENSP00000328570	bolA homolog 3 (E. coli)	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	0.881
BOLA3	HSCB	ENSP00000331369	ENSP00000216027	bolA homolog 3 (E. coli)	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	0.675
BOLA3	IBA57	ENSP00000331369	ENSP00000355672	bolA homolog 3 (E. coli)	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	0.728
BOLA3	ISCU	ENSP00000331369	ENSP00000310623	bolA homolog 3 (E. coli)	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	0.482
BOLA3	LIPT2	ENSP00000331369	ENSP00000309463	bolA homolog 3 (E. coli)	lipoyl(octanoyl) transferase 2 (putative); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)	0.416
BOLA3	LYRM4	ENSP00000331369	ENSP00000443900	bolA homolog 3 (E. coli)	LYR motif containing 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis	0.500
BOLA3	NUBPL	ENSP00000331369	ENSP00000281081	bolA homolog 3 (E. coli)	nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits	0.672
GLRX5	BOLA3	ENSP00000328570	ENSP00000331369	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	bolA homolog 3 (E. coli)	0.881
GLRX5	HSCB	ENSP00000328570	ENSP00000216027	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	0.762
GLRX5	IBA57	ENSP00000328570	ENSP00000355672	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	0.774
GLRX5	ISCA1	ENSP00000328570	ENSP00000365159	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly	0.853
GLRX5	ISCA2	ENSP00000328570	ENSP00000452007	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	iron-sulfur cluster assembly 2 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity)	0.856
GLRX5	ISCU	ENSP00000328570	ENSP00000310623	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	0.794
GLRX5	LYRM4	ENSP00000328570	ENSP00000443900	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	LYR motif containing 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis	0.746
GLRX5	NFS1	ENSP00000328570	ENSP00000363205	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	NFS1 nitrogen fixation 1 homolog (S. cerevisiae); Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor	0.801
GLRX5	NUBPL	ENSP00000328570	ENSP00000281081	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits	0.471
HSCB	BOLA3	ENSP00000216027	ENSP00000331369	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	bolA homolog 3 (E. coli)	0.675
HSCB	GLRX5	ENSP00000216027	ENSP00000328570	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1	0.762
HSCB	IBA57	ENSP00000216027	ENSP00000355672	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	0.754
HSCB	ISCA1	ENSP00000216027	ENSP00000365159	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly	0.870

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